The Co-Morbidity between Bipolar and Panic Disorder in Fibromyalgia Syndrome
Authors/Creators
- 1. Department of Clinical Neurosciences, Hermanas Hospitalarias, Villa San Benedetto Menni Hospital, Albese con Cassano, via Roma 16, 22032 Como, Italy; AND Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve, Emanuele-Milan, Italy
- 2. Rheumatology Unit, Department of Internal Medicine, University of Messina, Via Consolare Valeria 1, 98100 Messina, Italy;
- 3. Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Via GB Grassi 74, 20157 Milan, Italy
Description
The Co-Morbidity between Bipolar and Panic Disorder in Fibromyalgia Syndrome
About half of the patients with fibromyalgia (FM) had a lifetime major depression episode
and one third had a panic disorder (PD). Because the co-morbidity between bipolar disorder (BD)
and PD marks a specific subtype of BD we aimed to investigate if co-morbid BD/PD (comBD/PD)
occurs more frequently than the single disorder in FM patients and evaluate the clinical significance
and timing of this co-morbidity. Further, we explored the role of co-morbid subthreshold BD and PD.
In 118 patients with FM, lifetime threshold and sub-threshold mood disorders and PD were diagnosed
with Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) Clinical
Interview. Demographic and clinical variables were compared in co-morbid BD/PD (comBD/PD)
and not co-morbid BD/PD (nocomBD/PD) subgroups. The co-morbidity BD/PD was seen in 46.6%
of FM patients and in 68.6% when patients with minor bipolar (MinBD) and sub-threshold panic
were included. These rates are higher than those of the general population and BD outpatients.
There were no statistically significant dierences between threshold and sub-threshold comBD/PD
and nocom-BD/PD subgroups in demographic and clinical parameters. In the majority of patients
(78.2%), the onset of comBD/PD preceded or was contemporary with FM. These findings support the
hypothesis that comBD/PD is related to the development of FM in a subgroup of patients.
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Related works
- Is supplement to
- 10.3390/jcm9113619 (DOI)