Published December 23, 2021 | Version v1
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Association of serum biomarkers with post-thrombolytic symptomatic intracranial hemorrhage in stroke: A comprehensive protein microarray analysis from INTRECIS study

Authors/Creators

  • 1. Shenyang Pharmaceutical University
  • 2. Haicheng Hospital of Traditional Chinese Medicine
  • 3. Chinese People's Liberation Army 321 Hospital
  • 4. Jiamusi University First Affiliated Hospital
  • 5. Second Affiliated Hospital of Harbin Medical University
  • 6. General Hospital of Northern Theatre Command

Description

The study consecutively and prospectively collected blood samples from stroke patients in the INTRECIS study to investigate biomarkers associated with symptomatic intracranial hemorrhage after intravenous thrombolysis through comprehensively screening 49 pre-set biomarkers in microarray protein analysis. In the present study, we found baseline serum levels of CRP, GDNF, IFN-γ, IGFBP-6, IL-4, LYVE-1, MMP-2, PAI-1, and PDGF-AA were associated with post-thrombolytic symptomatic intracranial hemorrhage in acute ischemic stroke. Furthermore, PDGF-AA, IGFBP-6, and LYVE-1 were firstly found associated with symptomatic intracranial hemorrhage.

Notes

The study was funded by grants from National Key R&D Program of China (2017YFC1308200), and the Project on Research and Application of Effective Intervention Techniques for Chinese Stroke Guidelines from the National Health and Family Planning Commission in China (GN-2016R0008).

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