Stereoselective photodimerization and antimicrobial activities of heteroaryl chalcones and their photoproducts

School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain-456 010, Madhya Pradesh, India
E-mail : drshubhajain@yahoo.com
Government College, Barnagar-456 771, Madhya Pradesh, India
E-mail : rekha.nagwanshi@gmail.com
LNCT College, RGPV, Bhopal, Madhya Pradesh, India
Manuscript received 09 July 2010, accepted 21 March 2011

Stereoselective photodimerization of heteroaryl chalcones 1-(furan-2-yl)-3-phenylprop-2-en-1-one (1), 3-phenyl-1-(thiophen-2-yl)prop-2-en-1-one (2) and 3-phenyl-1-(lH-pyrrol-2-yl)prop-2-en-1-one (3) has been studied. The heteroaryl chalcones and their photoproducts have also been tested for antimicrobial activity. The heteroaryl chalcones (1-3) showed good activity with minimum inhibitory concentration (MIC) in the range of 10-60 µg/ml. The comparison of percentage antimicrobial activities relative to that of standards revealed that the monomeric starting compounds were more active than the dimerization products.