Published July 26, 2022
| Version v1
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YB1 dephosphorylation attenuates atherosclerosis by promoting CCL2 mRNA decay
Authors/Creators
Authors/Creators
- 1. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China
- 2. Jilin Zhongtai Biotechnology Co., LTD, Jilin, China
- 3. The Pathology Department, Beijing Hospital of Traditional Chinese Medicine, the Capital Medical University, Beijing, China
Description
Y-box binding protein 1 (YB1) is an RNA binding protein (RBP) that has been reported to play important roles in inflammation and atherosclerotic plaque formation. To explore the molecular mechanism of phosphorylated YB1 (pYB1) in atherosclerosis in vitro, we constructed YB1 phosphorylation site (Ser-100) mutant stable smooth muscle cell line (3ds-V5) and performed RNA profile screening through RNA-seq. We found inflammatory pathways and CCL2 was significantly decreased in the 3dS-V5 YB1 mutant compared with the control group (YB1-V5).
Files
Processed RNA-seq data of YBX1_and_3ds.zip
Files
(3.2 MB)
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