Antibacterial activity of N-bromonicotinamide

Postgraduate and Research Department of Chemistry, Postgraduate Department of Biotechnology,

National College, Tiruchirappalli-620 001, Tamilnadu, India

E-mail : viveksabapathi@gmail.com

Manuscript received 21 September 2010, revised 21 February 2012, accepted 02 April 2012

A new oxidant, N-bromonicotinamide was synthesized and screened for antibacterial activity in nutrient glucose agar medium disc diffusion method. The bacterial species used were Bacillus subtilis, Clostridium butyricum, Emerobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Commercial Amikacin (AK) 30 µg disc was used as positive control and the zone of inhibition was measured in mm and compared with the control. The experiment was carried out in triplicate for all concentrations. N-Bromonicotinamide showed significant antibacterial activity and can be utilized in new antibacterial formulations.