Laboratórna Diagnostika
Published December 6, 2021 | Version v1
Journal article Open

Sledovanie expresie ErbB2 amplikónu vzhľadom na úspešnosť IVF procesu / Monitoring the expression of ErbB2 amplicon concerning the success of the IVF process

Authors/Creators

  • 1. Ústav lekárskej a klinickej biochémie, UPJŠ LF, Košice, Slovakia
  • 2. Gynekologicko-pôrodnícka klinika, Univerzita Pavla Jozefa Šafárika, Lekárska fakulta, Košice, Slovakia

Description

SÚHRN

Neplodnosť je globálny zdravotný problém ovplyvňujúci ľudí v reprodukčnom veku. Na základe dostupných údajov neplodnosťou trpí 186 miliónov jednotlivcov na celom svete, v dôsledku čoho dochádza aj k nárastu cyklov umelého oplodnenia, in vitro fertilizácií (IVF). Cieľom predkladanej štúdie bola detekcia proteínov ErbB2 amplikónu v sére žien zaradených do IVF programu. Získané výsledky koncentrácie proteínov ErbB2 amplikónu naznačujú, že dereguláciou expresie ErbB2 amplikónu, môže dochádzať aj ku zmenám na úrovni angiogenézy u neplodných pacientiek. Výsledky predkladanej pilotnej štúdie prispievajú k prehĺbeniu poznatkov o zmenách v koncentráciách proteínov ErbB2 amplikónu a ich význame pri štúdiu neplodnosti v IVF procese.

ABSTRACT

Infertility is a global health problem affecting people of reproductive age. Based on available data, 186 million individuals worldwide suffer from infertility, resulting in an increase in vitro fertilization (IVF). The aim of the present study was to detect ErbB2 amplicon proteins in the serum of women in the IVF process. The results obtained with ErbB2 amplicon levels suggest that deregulation of ErbB2 amplicon expression can lead to changes in the level of angiogenesis in infertile patients. The results of the present pilot study contribute to the deepening of knowledge about changes in ErbB2 amplicon protein concentrations and their importance in the study of infertility in the IVF process.

Notes

Práca vznikla na základe grantovej podpory: VEGA 1/0873/18, VEGA 1/0620/19. Tieto projekty sú realizované v spolupráci s Gynekologicko-pôrodníckou klinikou UPJŠ LF a UNLP v Košiciach a Centrom pre asistovanú reprodukciu Gyncare v Košiciach. The work was created on the basis of grant support: VEGA 1/0873/18, VEGA 1/0620/19. These projects are implemented in cooperation with the Gynecology and Obstetrics Clinic of UPJŠ LF and UNLP in Košice and the Center for Assisted Reproduction Gyncare in Košice.

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