Published December 1, 2021 | Version v1

Occurrence of two abdominal neurofibromas in a specimen of Betta splendens

  • 1. Laboratory of Immunology and Pathology of Aquatic Organisms, Institute of Oceanography, Federal University of Rio Grande, 96210030, Rio Grande, Brazil.

Description

ABSTRACT | In this work we describe two neurofibromas in Betta splendens studied with optical microscopy, immunohistochemistry and electron microscopy. The specimen studied, that belonged to a private breeder, had marked abdominal distension, and was transferred for diagnosis to the Laboratory of Immunology and Pathology of Aquatic Organisms of the Universidade Federal do Rio Grande – FURG. It was diagnosed as neurofibroma, positive for the antibody to protein S-100. With electronic microscopy, it showed signs of degeneration in some cells and contained mast cells (MC) regularly distributed in the neoplasm mass. With immunohistochemistry we confirmed the histogenesis of the neoplasm, in which there were two neurofibromas, and with electron microscopy we confirmed that the granular cells within the neoplastic tissue were MCs.

RESUMEN | En este trabajo describimos dos neurofibromas en Betta splendens estudiados con microscopía óptica, inmunohistoquímica y microscopía electrónica. El espécimen estudiado, que pertenecía a un criador privado, presentaba marcada distensión abdominal, fue trasladado para diagnóstico al Laboratorio de Inmunología y Patología de Organismos Acuáticos de la Universidade Federal do Rio Grande – FURG. Fue diagnosticado como neurofibroma, positivo para el anticuerpo contra proteína S-100. Con microscopia electrónica, mostraba signos de degeneración en algunas células y contenía mastocitos distribuidos regularmente en la masa neoplásica. Con inmunohistoquímica confirmamos la histogénesis de la neoplasia, en la que existen dos neurofibromas, y con microscopía electrónica confirmamos que las células granulares que se encuentran entre el tejido neoplásico son MC.

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