Published December 10, 2015
| Version v1
Journal article
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In vivo imaging of system xc as a novel approach to monitor multiple sclerosis
Description
Glutamate excitotoxicity contributes to oligodendroglial and axonal damage in multiple sclerosis pathology. Extracellular glutamate concentration in the brain is controlled by cystine/glutamate antiporter (system xc), a membrane antiporter that imports cystine and releases glutamate. Despite this, the system xc activity and its connection to the inflammatory reaction in multiple sclerosis (MS) is largely unknown.
Notes
This study was funded by MINECO SAF2010-21547 and SAF2013-45084-R (C. M) and SAF2014-54070-JIN (A.M), FEDER, Department of Industry of Basque Government (IE14-385) and CIBERNED.
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