Published November 23, 2021 | Version r1

Summary statistics for association tests between human and Plasmodium falciparum genetic variants in 3,346 severe malaria cases from The Gambia and Kenya

Description

This dataset contains summary statistics for association tests between human and
Plasmodium falciparum malaria parasite genetic variants, using data from 3,346 severe malaria cases from The Gambia and Kenya.  These results underlie the analysis described in our paper:

"Malaria protection due to sickle haemoglobin depends on parasite genotype"

Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia M. Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski

Nature (2021) doi: 10.1038/s41586-021-04288-3 bioRxiv link:: doi.org/10.1101/2021.03.30.437659

The genotype data underlying these summary statistics has also been deposited on Zenodo
(doi:10.5281/zenodo.4973477).  The HPTEST software used to generate these results has also been deposited (doi:10.5281/zenodo.5685580).  Please see the MalariaGEN website for a full list of datasets which have been released with this manuscript.

Data contents.

The dataset consists of a single sqlite database file containing the results, and an accompanying README file in markdown and html format.  Please see the README file for full details of the data contents.

 

Files

hspf_summary_statistics.sqlite.zip

Files (4.3 GB)

Name Size
md5:1f2fcade9e60da20c1da02cb60eb377f
4.3 GB Preview Download
md5:604685ec05f5c0033805c26cbfcd4381
36.9 kB Download
md5:5586c90c8d4afa55dd1cb6897d52e500
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Additional details

Related works

Is derived from
Dataset: 10.5281/zenodo.4973476 (DOI)
Is supplement to
Preprint: 10.1101/2021.03.30.437659) (DOI)