Summary statistics for association tests between human and Plasmodium falciparum genetic variants in 3,346 severe malaria cases from The Gambia and Kenya
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Band, Gavin1
- Leffler, Ellen M.2
- Jallow, Muminatou3
- Sisay-Joof, Fatoumatta3
- Ndila, Carolyne M.4
- Macharia, Alexander M.4
- Hubbart, Christina1
- Jeffreys, Anna E.1
- Rowlands, Kate1
- Nguyen, Thuy5
- Gonçalves, Sónia5
- Ariani, Cristina V.5
- Stalker, Jim5
- Pearson, Richard D.5
- Amato, Roberto5
- Drury, Eleanor5
- Sirugo, Giorgio3
- d'Alessandro, Umberto3
- Bojang, Kalifa A.3
- Marsh, Kevin4
- Peshu, Norbert4
- Conway, David J.3
- Williams, Thomas N.4
- Rockett, Kirk A.1
- Kwiatkowski, Dominic P.5
- 1. University of Oxford
- 2. University of Utah
- 3. Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- 4. KEMRI-Wellcome Trust Research Programme
- 5. Wellcome Sanger Institute
Description
This dataset contains summary statistics for association tests between human and
Plasmodium falciparum malaria parasite genetic variants, using data from 3,346 severe malaria cases from The Gambia and Kenya. These results underlie the analysis described in our paper:
"Malaria protection due to sickle haemoglobin depends on parasite genotype"
Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia M. Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski
Nature (2021) doi: 10.1038/s41586-021-04288-3 bioRxiv link:: doi.org/10.1101/2021.03.30.437659
The genotype data underlying these summary statistics has also been deposited on Zenodo
(doi:10.5281/zenodo.4973477). The HPTEST software used to generate these results has also been deposited (doi:10.5281/zenodo.5685580). Please see the MalariaGEN website for a full list of datasets which have been released with this manuscript.
Data contents.
The dataset consists of a single sqlite database file containing the results, and an accompanying README file in markdown and html format. Please see the README file for full details of the data contents.
Files
hspf_summary_statistics.sqlite.zip
Additional details
Related works
- Is derived from
- Dataset: 10.5281/zenodo.4973476 (DOI)
- Is supplement to
- Preprint: 10.1101/2021.03.30.437659) (DOI)