Institut za onkologiju i radiologiju Srbije / Institute for Oncology and Radiology of Serbia
Published September 6, 2021 | Version v.1
Journal article Restricted

Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard's T and P reagents

Creators

  • 1. University of Belgrade-Faculty of Chemistry, Studentski trg 12–16, 11000, Belgrade, Serbia
  • 2. Dipartimento di Scienze Chimiche, della Vita e Della Sostenibilità Ambientale, Università Degli Studi di Parma, Viale delle Scienze, 17A, 43124, Parma, Italy Biopharmanet-TEC, Università Degli Studi di Parma, via Parco Area delle Scienze 27/A, 43124, Parma, Italy
  • 3. Institute of Oncology and Radiology of Serbia, 11000, Belgrade, Serbia
  • 4. University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000, Belgrade, Serbia
  • 5. University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000, Belgrade, Serb

Description

In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested.

Notes

Funding projects: Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)

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Additional details

Related works

Is identical to
10.1007/s00775-021-01893-5 (DOI)
Is part of
1432-1327 (ISSN)