Synthesis, spectral and antimicrobial evaluation of CoII, NiII, CuII and ZnII metal complexes of N-(furan-2-yl)-methylene-N-[(3-methyl-2H-benzo[e][1,2,4]- oxadiazin-2-yl)-phenyl-methylene]-hydrazine

Department of Chemistry, Institute of Basic Sciences, Dr. B. R. Ambedkar University, Khandari Campus,

Agra-282 002, Uttar Pradesh, India

E-mail : devendrakumar131@gmail.com

Manuscript received online 20 August 2013, revised 30 August 2014, accepted 06 October 2014

A novel series of metal complexes of Co^II, Ni^II, Cu^II and Zn^II of N-(furan-2-yl)-methylene-N-[(3-methyl-2H-benzo[e][1,2,4]oxadiazin-2-yl)-phenyl-methylene]-hydrazine were synthesized and characterized by their melting point determination of recrystallized samples, running TLC for single spot, elemental analysis, molar conductance, molecular weight determination, IR, ¹H NMR, magnetic moment values, electronic spectral and thermal studies. All the synthesized compounds, viz. (3-methyl-2H-benzo[e][1,2,4]oxadiazin-2-yl)-phenyl-methanone (2), 3-phenyl-3-(3-methyl-2H-benzo[e][1,2,4]- oxadiazin-2-yl)-hydrazone (3), N-(furan-2-yl)-methylene-N-[(3-methyl-2H-benzo[e][1,2,4]oxadiazin-2-yl)-phenyl-methylene]- hydrazine (4) and their metal complexes (5a-d) were screened for antimicrobial activities in vitro against Gram +ve bacteria (Staphylococcus aureus) and Gram –ve bacteria (Escherichia coli) and two fungi Aspergillus niger and Aspergillus flavus. Compound 2 exhibited significant antimicrobial activity which increased in its hydrazone (3). The activity further increased in the form of its derivative (4). Although all metal complexes exhibited maximum activity against both bacteria and fungi but the metal complex of Cu^II was found most active.