Oxidation of oxime derivative of friedelin with hydrogen peroxide in presence of selenium dioxide in tert-butanol and antimicrobial activity of the isolated compounds

Department of Chemistry, University of North Bengal, P.O. North Bengal University, Darjeeling-734 013,

West Bengal, India

E-mail : pizy12@yahoo.com Fax : 91-353-2699001

Manuscript received online 30 August 2013, accepted 03 June 2016

Oxime derivative (1a) of friedelin (1) on oxidation with hydrogen peroxide and selenium dioxide in tertiary butanol furnishes an ɛ-lactone, friedelolactone (2) and 2,3-seco-friedelonic acid (3). The structures of these compounds have been fully established on the basis of spectral data (IR, MS, PMR, and ¹³C NMR). Antimicrobial activity of the compounds were also investigated and the results are reported herein.