Synthesis of heterocycles containing pyrimidine-acridine rings by microwave irradiation, antimicrobial study and its comparison with classical heating

Department of Chemistry, Shri R. L. T. College of Science, Akola-444 001, Maharashtra, India

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New series of linked heterocycles containing acridine and pyrimidines were prepared in high yield from condensation of N-acridin-9-yl-3-oxo-butyramide with urea or thiourea or guanidine by microwave irradiation and by conventional heating for comparative study purpose. The representative compounds characterized on the basis of IR, ¹H NMR and Mass spectral beside elemental analysis. Microwave assisted synthesized compounds evaluated for their antimicrobial screening against selected microorganisms and some of them found to possess equipotent activity when compared with standard drug.