Study of multi drug resistant S.typhi and MIC in Ausa and Latur region in Maharashtra state of India

ABSTRACT:

Enteric (typhoid) fever is a systemic disease characterized by fever and abdominal pain caused by dissemination of Salmonella Typhi or Salmonella Paratyphi type A, B, or C. Fever (38.8-40.5°C; 101.8-104.9°F) is documented at presentation in more than 75% of cases and is typically prolonged, continuing up to 4 weeks if untreated. Symptoms reported on initial medical evaluation include headache (80%), chills (35-45%), cough (30%), sweating (20-25%), myalgias (20%), malaise (10%), and arthralgia (2-4%). Gastrointestinal (GI) symptoms include anorexia (55%), abdominal pain (30-40%), nausea (18-24%), vomiting (18%), and diarrhea (22-28%) more commonly than constipation (13-16%). In a series in Delhi, India, only 527 isolates were obtained from 5,735 suspected cases (9.2%)(5).

This compares with 175 isolates in 243 cases (72%) in Rodesia(8) and 219 isolates from 298 clinical cases in a pediatric group in Natal(73%)(4).after removal of the serum and dissolution of the clot with streptokinase(6). Bile broth and Streptokinase broth were used. In the isolation both bill salt broth (broth culture) and streptokinase broth (clot culture) where used for the enrichment of blood samples.