The Agaricales are the largest clade of mushroom-forming fungi, in Colombia, with 544 species of the approximately 16,000 species currently recognized worldwide in the phylum Basidiomycota. We document seven species of Agaricaceae for the first time from the Colombian Caribbean region. Two of these species are newly recorded from the country: Leucoagaricus lilaceus Singer and Leucoagaricus roseilividus (Murrill) E. Ludw. Five species are reported from the Colombian Caribbean for the first time: Agaricus griseorimosus Pegler, Chlorophyllum hortense (Murrill) Vellinga, Leucoagaricus rubrotinctus (Peck) Singer, Leucocoprinus cepistipes (Sowerby) Pat., and L. venezuelanus Dennis.