Published December 1, 2021 | Version v1
Journal article Open

In vivo Architecture of the Telomerase RNA Catalytic Core in Trypanosoma brucei

Authors/Creators

  • 1. University of North Carolina-Chapel Hill
  • 2. University of North Carolina at Charlotte
  • 3. Cleveland State University

Description

This dataset describes the RNA SHAPE (NAI) and DMS reactivities obtained for the catalytic core and Helix IV domain of Telomerase RNA from pathogen Trypanosoma brucei which causes African sleeping sickness. This study was conducted on both Bloodstream Form (Mammalian infective stage) and Procyclic Form (insect infective stage) of Trypanosoma brucei to determine its Telomerase RNA architecture.  The data was collected across different samples like in vivo, ex vivo, Immunopurified and in vitro transcribed Trypanosoma brucei Telomerase RNA. RNA sequences studied along with the protocol used are also provided in the dataset.

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