Journal article Open Access

STUDY OF THE CNS ACTIVITIES OF MIMOSA PUDICA Linn. IN ANIMAL MODEL

R. Naga Kishore*, A.Teja Sri, N.Anjaneyulu, Ch.Ramanikanth, A.Divya, K.Sainath and L.Saneela Suri

The present study was undertaken to evaluate the effects of CNS of Mimosa Pudica Linn. Mimosa pudica is a creeping annual or perennial herb of the pea family Fabaceae often grown for its curiosity value: the compound leaves fold inward and droop when touched or shaken, defending themselves from harm, and re-open a few minutes later. aqueous leaf extract of Mimosa Pudica suspended in water in presence of 3%v/v Tween-80 solution were administered orally. All the drugs were administered i.p for experimental purpose. Adult albino mice (25-30gms) of either sex were used for the study. The animals were divided into three groups containing of 6 animals of each group-1 received normal saline, group-2 received standard drug and group-3 received test drug aqueous extract of Plant extract (MP) maintained in a well-ventilated room with 12:12 hour light/dark cycle in polypropylene cages. Locomotor activity results showed that plant extract treated mice exhibited significant result when compared with that of standard in improvement of locomotor performance. Elevated Plus Maze is used to evaluate psychomotor performance and emotional aspects of rodents. Results showed that plant extract treated mice exhibited significant increase in the number of open arm entries. The number of arm entries, but decreases in time spent in closed arm reflects anxiolytic property. Rota rod test, the difference in the fall of time from the rotating rod between the vehicle and extract treated groups were taken as an index of muscle relaxation. Test drug showed significant decrease in the locomotory score and fall of time of the mice from the rotating rod. From the above observations we can conclude that aqoues extract of Mimosa pudica possesses significant CNS activities at both the dose level which is comparable with the standard. Keywords: Mimosa Pudica, Actophotometer, Rotarod

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