Multiomics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19
Creators
- Sacco, Keith1
- Castagnoli, Riccardo1
- Vakkilainen, Svetlana1
- Liu, Can1
- Delmonte, Ottavia M.1
- Oguz, Cihan1
- Kaplan, Ian M.2
- Alehashemi, Sara1
- Burbelo, Peter D.3
- Bhuyan, Farzana1
- A. de Jesus, Adriana1
- Dobbs, Kerry1
- Rosen, Lindsey B.1
- Cheng, Aristine1
- Shaw, Elana1
- Vakkilainen, Mikko S.4
- Pala, Francesca1
- Lack, Justin1
- Zhang, Yu1
- Fink, Danielle L.5
- Oikonomou, Vasileios1
- Snow, Andrew L.6
- Dalgard, Clifton L.6
- Chen, Jinguo7
- Sellers, Brian A.7
- Montealegre Sanchez, Gina A.1
- Barron, Karyl1
- Rey, Emma8
- Vial, Cecilia8
- Poli, Maria Cecilia8
- Licari, Amelia9
- Montagna, Daniela9
- Marseglia, Gian Luigi9
- Licciardi, Francesco10
- Ramenghi, Ugo11
- Discepolo, Valentina12
- Vecchio, Andrea Lo12
- Guarino, Alfredo12
- Eisenstein, Eli M.13
- Imberti, Luisa14
- Sottini, Alessandra14
- Biondi, Andrea15
- Mató, Sayonara16
- Gertsbacher, Dana17
- Truong, Meng1
- Stack, Michael A.1
- Magliocco, Mary1
- Bosticardo, Marita1
- Kawai, Tomoki1
- Danielson, Jeffrey J.1
- Hulett, Tyler1
- Askenazi ,Manor1
- NIH, NIAID Immune Response to COVID Group1
- Chile, Chile MIS-C Group8
- Pavia, Pavia Pediatric COVID-19 Group9
- Cohen, Jeffrey I.1
- Su, Helen C.1
- Kuhns, Douglas B.5
- Lionakis, Michail S.1
- Snyder, Thomas M.2
- Holland, Steven M.1
- Goldbach-Mansky, Raphaela1
- Tsang, John S.1
- Notarangelo, Luigi D.1
- 1. NIAID
- 2. Adaptive Biotechnologies
- 3. NIDCR
- 4. Aalto University
- 5. FNLCR
- 6. USUHS
- 7. CHI
- 8. Facultad de Medicina Clínica Alemana Universidad del Desarrollo
- 9. Fondazione IRCCS Policlinico San Matteo
- 10. Regina Margherita Children's Hospital17
- 11. Regina Margherita Children's Hospital
- 12. University of Naples Federico II
- 13. Hadassah-Hebrew University Medical Center
- 14. ASST Spedali Civili di Brescia
- 15. MetabERN-University of Milano-Bicocca-Fondazione MBBM- Ospedale San Gerardo
- 16. Randall Children's Hospital at Legacy Emanuel
- 17. Stanford Children's Hospital
Description
This repository contains the CITE-Seq data set used in the manuscript titled "Multiomics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19". This data set is composed of the expression levels of 188 surface proteins, RNA expression, and BCR/TCR repertoire in single peripheral blood mononuclear cells from 7 multisystem inflammatory syndrome in children (MIS-C) and 8 pediatric COVID-19 patients, in addition to 7 age- and sex-matched pediatric healthy controls.
1. misc_SeuratObj_submission.rds -- Seurat object contains all count data used for the manuscript
- raw sequencing data are not provided due to privacy issue
- metadata is included in the Seurat object
2. MIS-C_cohort_citeseq.xlsx -- sample meta data
3. immcant_bcr_ighl_filtered.csv -- single cell BCR data
4. TCR_filtered_contig_annotations.csv -- single cell TCR data
5. README.txt -- Descriptions of the individual data files
Notes
Files
immcant_bcr_ighl_filtered.csv
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