Published September 17, 2021
| Version v1
Dataset
Open
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1
Authors/Creators
-
Harding, Rachel J1
- Deme, Justin
- Hevler, Johannes F
- Tamara, Sem
- Lemak, Alexander
- Cantle, Jeffrey P
- Szewczyk, Magdalena M
- Begeja, Nola
- Goss, Siobhan
- Zuo, Xiaobing
- Loppnau, Peter
- Seitova, Alma
- Hutchinson, Ashley
- Fan, Lixin
- Truant, Ray
- Schapira, Matthieu
- Carroll, Jeffrey B
- Heck, Albert JR
- Lea, Susan M
- Arrowsmith, Cheryl H
- 1. Structural Genomics Consortium University of Toronto
Description
Supplementary Data files to accompany manuscript by Harding et al "Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1"
- Supplementary Data 1 - Multiple sequence alignment for HTT used for Consurf analysis
- Supplementary Data 2 - Multiple sequence alignment for HAP40 used for Consurf analysis
- Supplementary Data 3 - Apo HTT cryo-EM map
- Supplementary Data 4 - HTT-HAP40 Q23 regularised SAXS profile
- Supplementary Data 5 - HTT-HAP40 Q54 regularised SAXS profile
- Supplementary Data 6 - HTT-HAP40 Δexon 1 regularised SAXS profile
- Supplementary Data 7 - XL-MS data
- Supplementary Data 8 - HTT-HAP40 ensemble weightings
- Supplementary Data 9 - HTT-HAP40 Q23 ensemble models
- Supplementary Data 10 - HTT-HAP40 Q54 ensemble models
- Supplementary Data 11 - HTT-HAP40 Δexon 1 ensemble models
Files
Supplementary_Data_1_HTT_MSA.txt
Files
(224.2 MB)
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