Poster Open Access
The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation
Pancaro, Alessia;
Szymonik, Michal;
Georgiou, Panagiotis G.;
Baker, Alexander N.;
Walker, Marc;
Adriaensens, Peter;
Hendrix, Jelle;
Gibson, Matthew I.;
Nelissen, Inge
The localised surface plasmon resonance (LSPR) peak of gold nanorods (GNRs) is located in the near-infrared optical window and is sensitive to local binding events, enabling label-free detection of biomarkers in complex biological fluids. Glycan-binding proteins, called lectins, play a key role in many biological processes.
To enable LSPR-based biosensing, the nanoparticles must be decorated with recognition units tethered to the surface by a ligand. We studied the sensing performance of GNRs coated with galactosamine-modified polymeric linkers for the detection of the lectin soybean agglutinin (SBA), used as a model analyte.
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- Publication date:
- September 10, 2021
- DOI:
-
- Keyword(s):
- gold nanorods nanomedicine
- Grants:
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European Commission:
- NanoCarb - Glyco-Nanoparticles for Applications in Advance Nanomedicine (814236)
- License (for files):
- Creative Commons Attribution 4.0 International