Poster Open Access

The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation

Pancaro, Alessia; Szymonik, Michal; Georgiou, Panagiotis G.; Baker, Alexander N.; Walker, Marc; Adriaensens, Peter; Hendrix, Jelle; Gibson, Matthew I.; Nelissen, Inge

The localised surface plasmon resonance (LSPR) peak of gold nanorods (GNRs) is located in the near-infrared optical window and is sensitive to local binding events, enabling label-free detection of biomarkers in complex biological fluids. Glycan-binding proteins, called lectins, play a key role in many biological processes.
To enable LSPR-based biosensing, the nanoparticles must be decorated with recognition units tethered to the surface by a ligand. We studied the sensing performance of GNRs coated with galactosamine-modified polymeric linkers for the detection of the lectin soybean agglutinin (SBA), used as a model analyte.

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