Synthesis of tosylated and trimethylsilylated methyl cellulose as pH-sensitive carrier matrix
Description
Lignocellulosic biomass is one of the most abundant renewable resources that can be processed by
chemical reactions for the production of value-added products. In the current study, cellulose and methyl cellulose
were synthesized from bleached bagasse pulp and were further modified to cellulose derivatives. Cellulose was first
extracted from bagasse by acid–alkali pulping process and was derivatized to prepare methyl cellulose. The products
were further chemically modified to tosylated methyl cellulose and trimethylsilylated methyl cellulose. The resulting
products were investigated by FT-IR and SEM. Cellulose and all derivatives prepared were evaluated as potential
pH-sensitive carrier matrices. The effectiveness as carrier was investigated as function of pH and time in various pH
solutions, namely 2.0, 3.5 and 5.0. It was indicated that the type of the modified cellulose plays a role in the obtained
results. The present work can be considered as a basic line for drug loading and releasing field.