Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas
- 1. Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg
- 2. Max Delbrueck Center for Molecular Medicine/Institute of Biochemistry, Department of Biology, Chemistry and Pharmacy, Free University Berlin
- 3. Max Delbrueck Center for Molecular Medicine Berlin
- 4. Core Unite SysMed, University of Wuerzburg
- 5. Central Laboratory University Hospital, University of Wuerzburg
- 6. Max Delbrueck Center for Molecular Medicine Berlin/Berlin Institute of Health
- 7. Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Institute of Metabolism and System Research, University of Birmingham
- 8. Max Delbrueck Center for Molecular Medicine Berlin/Berlin Institute of Health/Core Unit SysMed, University of Wuerzburg
Description
Abstract
The human adrenal glands are highly dynamic endocrine organs that are involved in the secretion of various hormones such as steroids and catecholamines. Here we present a single-nuclei and spatial transcriptomic analysis of healthy adult human adrenal glands to provide a complete adrenal gland atlas. With this, we show how such an atlas can be taken advantage when studying adrenocortical diseases, such as adrenocortical adenomas (ACA). Using nornal adrenal as reference, we showed a high intra-tumoural heterogeneity in the single-nuclei transcriptome of ACA, revealing the presence of specific cell populations associated with cortisol secretion and genetic background.
Data content
This dataset contains the two Visium replicates (NAG-7A and NAG-7B) processed using Space Ranger (spaceranger-1.0.0).
Files
NAG-7A.zip
Files
(238.2 MB)
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