Published August 25, 2021
| Version 1
Dataset
Open
TREM2: A Target Enabling Package
Authors/Creators
Description
Single loss of function mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer’s disease and Nasu-Hakola disease. Therefore, drugs enhancing TREM2 activity represent a potential treatment strategy. We identified 4 TREM2-specific scFv antibody fragments by phage display and solved the crystal structures of two of these in complex with the TREM2 ectodomain. The scFv antibodies altered TREM2 ectodomain shedding and TREM2 downstream signalling, representing promising research tools and therapeutic antibodies.
Notes
This document represents version 1 of the TEP datasheet. For more information about TEPs and the TEP Programme, please visit https://www.cmd.ox.ac.uk/resources/teps
Files
TREM2 TEP_v1.pdf
Files
(2.5 MB)
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Additional details
Funding
- Wellcome Trust
- A UK Hub to Catalyse Open Target Discovery. 106169