Published August 23, 2021
| Version v1
Dataset
Open
Mass Spectrometry Datasets for "Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape"
Authors/Creators
-
Mast, Fred D.1
- Fridy, Peter C.2
- Ketaren, Natalia E.2
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Wang, Junjie3
- Jacobs, Erica Y.4
- Olivier, Jean Paul1
- Sanyal, Tanmoy5
- Molloy, Kelly R.3
- Schmidt, Fabian6
- Rutkowska, Magdalena6
- Weisblum, Yiska6
- Rich, Lucille M.7
- Vanderwall, Elizabeth R.7
- Dambrauskas, Nicholas1
- Vigdorovich, Vladimir1
- Keegan, Sarah8
- Jiler, Jacob B.2
- Stein, Milana E.2
- Olinares, Paul Dominic B.3
- Herlands, Louis9
- Hatziioannou, Theodora6
- Sather, D. Noah10
- Debley, Jason S.11
- Fenyö, David8
- Sali, Andrej5
- Bieniasz, Paul D.12
- Aitchison, John D.13
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Chait, Brian T.3
- Rout, Michael P.2
- 1. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, USA
- 2. Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA
- 3. Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA
- 4. Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA; Department of Chemistry, St. John's University, Queens, New York 11439, USA
- 5. epartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall, 1700 4th Street, Suite 503B, University of California, San Francisco, San Francisco, California 94143, USA
- 6. Laboratory of Retrovirology, The Rockefeller University, New York, New York 10065, USA
- 7. Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington 98109, USA
- 8. Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU, Grossman School of Medicine, New York 10016, USA
- 9. AbOde Therapeutics Inc., 13 Church Street, Woods Hole, Massachusetts 02543, USA
- 10. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, USA; Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
- 11. Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington 98109, USA; Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA; Division of Pulmonary and Sleep Medicine, Seattle Children's Hospital, Seattle, Washington 98105, USA
- 12. Laboratory of Retrovirology, The Rockefeller University, New York, New York 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA
- 13. Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, USA; Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Description
This repository contains mass spectrometry raw datasets for the research paper "Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape". An early version of the manuscript can be viewed on bioRxiv.
The datasets include two parts:
- Identification of nanobodies targeting SARS-CoV-2 spikes.
- Chemical cross-linking of nanobody-spikes complexes.
The included .raw files are Thermo Orbitrap Raw files, and can be assessed by various software such as Thermo Xcalibur, ProteoWizard and pymsfilereader.