Planned intervention: On Wednesday April 3rd 05:30 UTC Zenodo will be unavailable for up to 2-10 minutes to perform a storage cluster upgrade.
Published October 1, 2021 | Version v2
Dataset Open

Genetic variation influencing DNA methylation provides new insights into the molecular pathways regulating genomic function - Selected Supplementary Tables

Description

Selected Supplementary Tables - ST5, 7, 8 and 9

Supplementary Table 5. Cosmopolitan results. Cosmopolitan SNP-CpG associations identified through genome-wide association amongst Europeans and South Asians.

Supplementary Table 7. Cross-tissue replication. Results for further testing of the 11,165,559 cosmopolitan SNP-CpG associations identified (by genome-wide association in blood), in 4 isolated white cell subsets (CD4+ lymphocytes, CD8+ lymphocytes, monocytes and neutrophils), in adipocytes isolated from subcutaneous adipose tissue or visceral adipose tissue, and in whole adipose tissue.

Supplementary Table 8. Conditional analysis. Results of conditional analysis to identify SNPs independently associated with each of the ~360K CpG sites tested. 

Supplementary Table 9. Sentinel SNPs and CpGs. Results of R2 pruning and locus merging to identify discrete genetic and methylation loci that are associated, and their respective sentinel SNPs and sentinel CpG sites. 

Other files (e.g. annotation files and 'intermediate' processing files) referenced in our code are also provided. 

 

Files

cosmo-cpgs.txt

Files (13.7 GB)

Name Size Download all
md5:705a6d1dc8a4227fdc38ba7683a22b94
169.6 MB Download
md5:549af5ec3c0e4a3ce441acc43b358471
164.3 MB Download
md5:bf0822fc29ad4449d1c5fbc4a6e4e432
193.6 MB Download
md5:67c66ff41021890fc15c5a88ff349afc
1.6 GB Download
md5:1c755d12a130dd33e37d2d0ce70666fb
777.8 kB Preview Download
md5:31bb3f44201745bb5db0d1a50449226c
28.5 MB Preview Download
md5:c53d28eb4d301c32503c3ee3f1f0d019
1.8 GB Download
md5:66a71859a8d795cb09eca7648068ceab
97.3 MB Download
md5:2253bd10d570b88e765e71dcb4a058aa
9.9 MB Download
md5:0f526c73aaa634b40710ab7916f8fdd6
24.2 MB Download
md5:f77c02a751cc82333f387564eed37ee4
9.7 MB Download
md5:d7bd65c5df1cf25d67b7cb50b4de1c03
149.8 MB Download
md5:73e0c2ec13cf6b7bb780a9cd01308848
4.4 MB Download
md5:dba6e001257beaddc7f1cfcc4b043e7e
6.7 MB Download
md5:400f24885c6cf8b6074c826a42a764ed
64.0 MB Download
md5:9e13cfce22521817b3bbd4bfd0125e6f
9.6 MB Preview Download
md5:6c93fcdffa31509fe042b484264cfd9d
5.3 MB Preview Download
md5:3d99b90b54296c08e4f128055562e1bc
250.6 MB Download
md5:f4ab21c68a191ba296ee6fe6fd94916c
12.0 MB Download
md5:81902b57cda59acd0d18420bcec2142e
608.4 kB Download
md5:f5dfbbd102d816c569b9d241bce35fa1
109.9 MB Download
md5:e771ee1a0404ab699dffac465aba64ee
3.2 GB Preview Download
md5:6051c1ac0bc1d5e5c9a882ad20ccecfb
5.4 GB Preview Download
md5:ab22c85f61e087dc939657bbb379e08f
17.8 MB Preview Download
md5:1eede6d786c10ef9fa924e068eca2b6d
875.1 kB Download
md5:992896ac6ee031060ac66177e9896aa1
355.1 MB Download
md5:d0e38b870227c314fa91eacf03dc06cd
784.9 kB Preview Download