Accompanying data set for the manuscript "REverSe TRanscrIptase Chain Termination (RESTRICT) for Selective Measurement of Nucleotide Analogs Used in HIV Care and Prevention"

This data set contains all experimental and theoretical data included in the manuscript " REverSe TRanscrIptase Chain Termination (RESTRICT) for Selective Measurement of Nucleotide Analogs Used in HIV Care and Prevention", namely:

RESTRICT_model: MATLAB script for completing calculations in the RESTRICT theoretical model.

Figure 2:

• Raw data from theoretical model showing contributions of individual model components, Kaff = 0.3
• Normalized data from theoretical model showing contributions of individual model components, Kaff = 0.3
• Experimental NRTI Drug Screen 180 nt TTCA 500 nM dNTP

Figure 3:

• Experiment-dNTP-Concentration-Screen
• Theory-dNTP-Concentration-Screen
• Experiment-Template-Length-Screen
• Theory-Template-Length-Screen
• Experiment-Sequence-Screen
• Theory-Sequence-Screen

Figure 4:

• Experimental-NRTI-Drug-Screen-90nt-TCAA-only
• Theory-TCAA90-Kaff=0point2
• Experimental-NRTI-Drug-Screen-GGCA-only
• Theory-GGCA180-Kaff=0point2

Figure 5:

• GGCA-vs-TTCA-Specificity-Analysis