Published July 26, 2021
| Version v1
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mass spectrometry metabolomic analysis of Drosophila head extracts: 3 genotypes (control, RNAi Opa1 in muscle, RNAi Marf in muscle), 2 ages (30 days, 65 days)
Description
RNAi of the Drosophila mitochondrial fusion genes Opa1 and Marf (Mitofusin 2) in the muscle results in an extended lifespan. In order to detect metabolic changes in lipid in the neural tissue, we analysed the metabolome of fly heads by mass spectroscopy, comparing the two knock-down genotypes to a wild type control at two ages: 30 days (young flies) and 65 days (old flies).
Notes
Work was funded by PROMETEU/2018/135 from "Consellería, de Sanitat de la Generalitat Valenciana". Part of the equipment employed in this work has been funded by Generalitat Valenciana and co-financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014–2020).
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