DATA to support Dyrk1a function in glutamatergic neurons in mouse models of Mental Retardation Disease 7 (MRD7) and Down syndrome (or trisomy 21)
Description
Four datasets are provided here to support the function of Dyrk1a in glutamatergic neurons in mouse models of Mental Retardation Disease 7 (MRD7) and Down syndrome (or trisomy 21):
- RNAseq data to compare hippocampal expressed genes at postnatal day 30, in the complete inactivation of Dyrk1a in glutamatergic neurons using a Dyrk1a floxed-allele and the Camk2:Cre transgene
- data from all the figures
-data from all the supplementary figures
-data from the quantitative proteomic analysis made from hippocampal extract of wt, Dyrk1a heterozygote, Dp(16)1Yey and Dp(16)1Yey with only two functional copies of Dyrk1a
Detailed information are available in the article by Brault et al 2021, deposited in Biorachiv https://doi.org/10.1101/2021.05.01.442242
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Additional details
Related works
- Is supplemented by
- Preprint: 10.1101/2021.05.01.442242 (DOI)
Funding
References
- Brault et al. (2021) Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome