Published June 26, 2021
| Version v1
Dataset
Open
Immunotherapy-mediated thyroid dysfunction: genetic risk and impact on outcomes with PD-1 blockade in non-small cell lung cancer
Authors/Creators
- Luo, Jia1
-
Martucci, Victoria L2
- Quandt, Zoe3
- Groha, Stefan4
- Murray, Megan H5
- Lovly, Christine M6
- Rizvi, Hira7
- Egger, Jacklynn V7
- Plodkowski, Andrew J8
- Abu-Akeel, Mohsen9
- Schulze, Isabell9
- Merghoub, Taha10
- Cardenas, Eduardo11
- Huntsman, Scott11
- Hu, Donglei11
- Li, Min11
- Gubens, Matthew A12
- Gusev, Alexander4
- Aldrich, Melinda C13
- Hellmann, Matthew D14
- Ziv, Elad15
- 1. Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 2. Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
- 3. Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, CA, USA; Diabetes Center, University of California, San Francisco, CA, USA
- 4. Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA
- 5. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
- 6. Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
- 7. Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 8. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 9. Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 10. Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 11. Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 12. Medical Oncology, University of California San Francisco, San Francisco, CA, USA; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA
- 13. Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
- 14. Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA
- 15. Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, Center for Genes, Environment and Health and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA
Description
Polygenic risk score weights derived using LDpred for hypothyroidism and thyroid medication use.
Files
hypothyroidism_PRS_snp_weights.txt
Files
(86.4 MB)
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