A dataset of human and Plasmodium falciparum genotypes in severe malaria cases from The Gambia and Kenya
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Gavin Band1
- Ellen M. Leffler2
- Muminatou Jallow3
- Fatoumatta Sisay-Joof3
- Carolyne M. Ndila4
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Alexander W. Macharia4
- Christina Hubbart1
- Anna E. Jeffreys1
- Kate Rowlands1
- Thuy Nguyen5
- Sonia M. Goncalves5
- Cristina V. Ariani5
- Jim Stalker5
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Richard D. Pearson5
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Roberto Amato5
- Eleanor Drury5
- Giorgio Sirugo3
- Umberto D'Alessandro3
- Kalifa A. Bojang3
- Kevin Marsh4
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Norbert Peshu4
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David J. Conway3
- Thomas N. Williams4
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Kirk A. Rockett1
- Dominic P. Kwiatkowski6
- 1. University of Oxford
- 2. University of Utah
- 3. MRC The Gambia at the LSHTM
- 4. KEMRI-Wellcome Trust Research Programme
- 5. Wellcome Sanger Institute
- 6. Wellcome Sanger Institute; University of Oxford
Description
This data release contains human and Plasmodium falciparum malaria genotypes from the article:
Malaria protection due to sickle haemoglobin depends on parasite genotype
Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne
M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy
Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto
Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin
Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor10, David J.
Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski
Nature (2021) doi: 10.1038/s41586-021-04288-3 bioRxiv link: doi.org/10.1101/2021.03.30.437659.
The release contains genotypes from human and Plasmodium falciparum genetic variants, genotyped using blood samples from 4,171 children ascertained with severe symptoms of malaria at the Royal Victoria Teaching Hospital (now the Edward Francis Small Teaching Hospital), The Gambia, and from the Kilifi District Hospital (now Kilifi County Hospital), Kenya in the period 1995-2009.
An accompanying set of association test summary statistics has also been released on Zenodo (doi: 10.5281/zenodo.5722497). Please see www.malariagen.net/resource/32 for full details of other resources associated with the above manuscript.
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Additional details
Related works
- Is supplement to
- Preprint: 10.1101/2021.03.30.437659 (DOI)