X-ray crystallographic studies of RoAb13 bound to PIYDIN, a part of the N terminal domain of C-C chemokine receptor 5: Sample 7 diffraction images

Short peptide (PIYDIN) Sample 7 diffraction images for 7nw3.

Publication:-

Govada, L., Saridakis, E., Kassen, S.C., Bin-Ramzi, A., Morgan, R.M., Chain, B., Helliwell, J.R. & Chayen, N.E. (2021). IUCrJ 8, https://doi.org/10.1107/S2052252521005340.

Article Synopsis:

C-C chemokine receptor 5 (CCR5) is a major co-receptor molecule used by HIV-1 to enter cells. Two X-ray crystallographic studies are presented of the antibody RoAb13, which binds to the peptide PIYDIN, which is part of the N-terminal domain of CCR5. The results may provide the basis for active immunization vaccines to stimulate an antibody response to native CCR5 that will block HIV infection.