A Meroisoprenoid, Heptenolides and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis
Authors/Creators
- 1. Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania
- 2. Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden
- 3. Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan Q1d 4111, Australia
- 4. Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada
Description
NMR data including FIDs, mnova files and NMReDATA.
A new meroisoprenoid (1), two heptenolides (2, 3), two C-benzylated flavonoids (4, 5) and eleven known compounds (6-16) were isolated from the leaf, stem bark and root bark extracts of Sphaerocoryne gracilis ssp. gracilis by chromatographic separation. The structures of the isolated metabolites were identified by NMR, IR and UV spectroscopic and mass spectrometric data analyses. (Z)-Sphaerodiol (7), (Z)-acetylmelodorinol (8), 7-hydroxy-6-hydromelodienone (10) and dichamanetin (15) inhibited the proliferation of Plasmodium falciparum (3D7, Dd2) with IC50 values of 1.4-10.5 μM; however, they showed cytotoxicity against human embryonic kidney cells (HEK-293). None of the compounds exhibited significant disruption in protein translation when assayed in vitro.
Notes
Files
Compound 1.zip
Files
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