Published May 31, 2021
| Version v2
Journal article
Open
Human inbreeding has decreased in time through the Holocene
Authors/Creators
- 1. Department of Biological Sciences, Middle East Technical University, 06800, Ankara, Turkey
- 2. Human-G Laboratory, Department of Anthropology, Hacettepe University, 06800, Ankara, Turkey
- 3. Department of Settlement Archaeology, Middle East Technical University, 06800, Ankara, Turkey
- 4. Department of Modeling and Simulation, Graduate School of Informatics, Middle East Technical University, 06800, Ankara, Turkey
- 5. Department of Archaeology and Classical Studies, Stockholm University, Stockholm, Sweden
Description
The history of human inbreeding is controversial. In particular, how the development of sedentary and/or agricultural societies may have influenced overall inbreeding levels is unclear. Here we present an approach for reliable estimation of runs of homozygosity (ROH) in genomes with ≥3x mean sequence coverage across >1 million SNPs, and apply this to 411 ancient Eurasian genomes from the last 15,000 years. We show that the frequency of inbreeding, as measured by ROH, has decreased over time. The strongest effect is associated with the Neolithic transition, but the trend has since continued, indicating a population size effect on inbreeding prevalence. We further show that most inbreeding in our historical sample can be attributed to small population size instead of consanguinity. We observed singular cases of high consanguinity only among members of farming societies.
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md5:cf3ee9a1aa38a6a8b8f50c33a211c873
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69.4 MB | Download |
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md5:cf01c80aa440486a0b419da5316f68b9
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69.8 MB | Download |
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md5:13869fe57c025d378c4b9b39e76f873e
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70.1 MB | Download |
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md5:0466014e6d97e5c1d04b8a3c5a67b804
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75.3 MB | Download |
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md5:7d149aa54bab3c337859a4bacfacb4c5
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73.2 MB | Download |
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md5:45a96dba1afe6cc672151bbdb0611828
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71.7 MB | Download |
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md5:1ea8c56cc995d5a0dec0549b0729a02c
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70.4 MB | Download |
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md5:9a03df5568e9a743c65085a5b96cbea3
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67.4 MB | Download |
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md5:78eec4390fe3e7f8839b51beedf8e7bd
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75.8 MB | Download |
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md5:fa43225bac630006ccc4d614d413c928
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68.9 MB | Download |
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md5:53a41090634bfc958bf15c1ec60039cc
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66.0 MB | Download |
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md5:843fcf6efc85d86f9c1687d0bde019cb
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82.1 MB | Download |
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md5:b5f07884b12cfc01241ca43600030806
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68.0 MB | Download |
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md5:8353820c2b25331144922e847802f252
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67.3 MB | Download |
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md5:61989f62c0b9273dbe1a04002afffad0
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65.0 MB | Download |
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md5:cd465f04359cb8078f97c8f85216564d
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66.8 MB | Download |
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md5:f4d4497a50399ac9b4071707072913ba
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86.0 MB | Download |
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md5:88623f57e4d827cd8b9839e1015ca282
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72.3 MB | Download |
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md5:f6b881c88a52237ee8388428617149dd
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67.0 MB | Download |
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md5:a2096f5a21ecc9306151f437f67a53ad
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66.7 MB | Download |
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md5:eb4b93770fe84187c733c5266c7fb390
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66.6 MB | Download |
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md5:be873972c9aa62b0ab440d8044dfbe7f
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67.0 MB | Download |
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md5:48f57165e7652fae29a5a9861e753297
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68.2 MB | Download |
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md5:dffa6351f595575db65f772976997772
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68.1 MB | Download |
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md5:c39f91ad2fdd43f42b08d59bb36b10a9
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65.9 MB | Download |
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md5:ba5e30d6f28bb37557876f698d39d64c
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67.1 MB | Download |
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md5:f674efac8d8a9649e68799ce04995bd2
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70.5 MB | Download |
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md5:385ba162443d585d0431412d288836fd
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64.3 MB | Download |
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md5:e041093dad58678971dd22f85f8c4f8d
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68.9 MB | Download |
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md5:e236f707ea149cbf28cddfa6466137d4
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73.0 MB | Download |
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md5:f276956c43b1548b9ccf979ff4dd3feb
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75.0 MB | Download |
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md5:86086426cd3732c8329bddf4dbfe76b7
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72.0 MB | Download |
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md5:74dfa662a06687c81aaa94386649a5e8
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72.1 MB | Download |
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md5:a21d1c1209a3b331f16b79c81c74e382
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72.6 MB | Download |
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md5:75ab0e5427587a65b44bc45ca29b1517
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74.1 MB | Download |
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md5:f3e33591e1bc598fcd29524c4aade6df
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73.7 MB | Download |
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md5:aeaa2b62c63731c2d226f0aa1121e719
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72.1 MB | Download |
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md5:7d91161475ac0ae8af0ba8f43c67676f
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71.8 MB | Download |
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md5:64de0228733720f861543d21e4ef652c
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72.5 MB | Download |
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md5:600bb0782fe905532e29afc00484b4df
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72.6 MB | Download |
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md5:e3348aee6bd8a1e120f8529cb4fd7239
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79.9 MB | Download |
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md5:269ba24e073c42dd626679aec03b224c
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77.8 MB | Download |
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md5:2d15d337cb0dd76448e676040c41d43b
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74.1 MB | Download |
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md5:1613c6b9b54a0c14599755a5b9ae2267
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73.4 MB | Download |
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md5:e76cdfb679e5e461c350bea8bc660ccf
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75.8 MB | Download |
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md5:8403aa0f8ef8faf8e7a1894fa75ce3f2
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73.4 MB | Download |
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md5:72ec764d712fd1ea7bcf53d132b6e8e8
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75.7 MB | Download |
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md5:4cae7dbbee1514ea2804481b1d73c036
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73.9 MB | Download |
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md5:f0195d2449b962ddc37e17b7fd693b7b
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74.8 MB | Download |
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md5:6096206cb85b252af8511cfabc4b39ea
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74.0 MB | Download |
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md5:59b53be637e804510a3a7cc98c527034
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74.5 MB | Download |
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md5:7da84186dfae311044750169d9925e6c
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78.6 MB | Download |
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md5:c0ab40712eef5a1a1d83a2cb181cf5c4
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74.1 MB | Download |
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md5:429e400c019059c2ad1757cfe2263311
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77.7 MB | Download |
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md5:686f695189d433e362541e90aa94c1f2
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74.7 MB | Download |
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md5:7aaca6866437828e31da5a08a4f2a4b0
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76.6 MB | Download |
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md5:005a3daa1eb6aa42603dc02a2ce4dbea
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78.3 MB | Download |
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md5:fa28a34593f8da517f2657a9f08ad3eb
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77.5 MB | Download |
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md5:06244c57be921b8f75ec44add20fd065
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75.8 MB | Download |
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md5:6d62cba13ffa037a2c47fe99034a3711
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77.0 MB | Download |
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md5:01734a14464a2fe122eae66e2daa6dea
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76.2 MB | Download |
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md5:84ffd86a35da798704ba174e600d34f8
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74.5 MB | Download |
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md5:4b4918e1ca746670fad5c224f740488d
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75.6 MB | Download |
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md5:1aa0de16493c78816169bf9c3c1c4236
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71.7 MB | Download |
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md5:f3fdbc207b913fbcf72a99a38139621b
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76.5 MB | Download |
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md5:7d2e4277435721af13e944826cb4cfff
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77.2 MB | Download |
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md5:cdf6e5635fe9e56f8ebd5fe0d9d04e1b
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75.0 MB | Download |
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md5:a6f0efc671bf86d4ab41c54fe7ac962d
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75.8 MB | Download |
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md5:56fab4a2c393615057e2d00a59b76bde
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78.2 MB | Download |
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md5:d1dae2cdd9dfd2eb86c1afb761d97166
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77.8 MB | Download |
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md5:c7237266d6d6adac013f8e15b2cc3a00
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74.7 MB | Download |
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md5:d7afab0cc75acf8a1ada2ee1c0f1f58d
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83.7 MB | Download |
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md5:1a45e967fdc08d00171f869c1d86bc05
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83.7 MB | Download |
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md5:552fc9789c6b212f10df74aeb4301dd0
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73.7 MB | Download |
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md5:d8e1c183114be81cc27cc1d5a17a37c8
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73.9 MB | Download |
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md5:13ae0cdb19d2356f5cd3845269237e3f
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68.9 MB | Download |
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md5:053b0a344bb1d04805ba458c37d1ddab
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77.1 MB | Download |
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md5:2e0512cd65b4d74d4966794b5de13bfc
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81.0 MB | Download |
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md5:f4e6a055c27a8b27e60ed606b0cbe552
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81.1 MB | Download |
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md5:7cb95358d8778885329d2365ad6c2e90
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79.3 MB | Download |
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md5:c08c351642df7eeabdcbe6cc566c2260
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86.1 MB | Download |
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md5:d1b252268f21a657172ebf855180c84d
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59.2 MB | Download |
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md5:21ef99d722d8db1ca6ba09a948c03111
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67.2 MB | Download |
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md5:26ef89e2d4deea15b0d1cec1dfeed9f3
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62.3 MB | Download |
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md5:0e26161a7858f4ad47b4372550704095
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57.5 MB | Download |
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md5:c6918354ecac9b15401928f5b52f6cd6
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59.9 MB | Download |
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md5:700911edb1485ec39ac1d4594b784cbf
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71.8 MB | Download |
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md5:6d63f23c329c2375e5860569315b0104
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75.3 MB | Download |
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md5:4b851f2f2d8c4f47b8562c199b9ce5a0
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72.2 MB | Download |
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md5:f516054398f5d4e57db0d678733d2cb8
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73.1 MB | Download |
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md5:d9ff9d51cf7b1b8f5374e289b3eb4780
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76.7 MB | Download |
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md5:397d18be220377784c35e6bf08bde4c3
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76.8 MB | Download |
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md5:6370dd363402a54f6ac9a80ad202b907
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74.5 MB | Download |
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md5:f03d741f7327f2a5430a682714bd54ba
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78.6 MB | Download |
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md5:881b77d1e9bb4e6f30e9d1befa8cab15
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78.2 MB | Download |
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md5:141fdc5ba676f542080b8b5142aa8e0d
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80.6 MB | Download |
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md5:242ba2c6317f86c8e9b3ce1644db2e5e
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75.3 MB | Download |
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md5:3ba92e945e4787dea135e4bf397a2073
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76.3 MB | Download |
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md5:e797b5017ca9c0a3e34dc7433b73e688
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76.5 MB | Download |
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md5:9214a07944ee589e6bf0ccb419a77763
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78.0 MB | Download |
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md5:d4babce38c3f4f9aab486b06da0d980d
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77.0 MB | Download |
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md5:b4028964d752ccda14e0b17915cebc5a
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77.9 MB | Download |
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md5:45a9a58e94c76b28bc948ec057ad4ff6
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76.5 MB | Download |
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md5:736c412010f93d8d3267e58288916caf
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71.3 MB | Download |
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md5:c8b52bad2298fa4ed1c313fa69861370
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76.1 MB | Download |
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md5:930ca61e0aa94009fcb3b72d369dc327
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76.2 MB | Download |
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md5:ce5a4d44c129325710fca4a85b01293b
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78.8 MB | Download |
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md5:c6e94b718567702b7f9a58c812cf5b2a
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77.5 MB | Download |
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md5:cd46b18ab78ec62288b852cb64e7b1d7
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77.3 MB | Download |
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md5:b1cb8aeec4745abd26af10eb4b4a7435
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78.2 MB | Download |
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md5:f464a4306728c0972a82e2d6d4440eaa
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79.1 MB | Download |
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md5:a82b1ef8e46df53c0280f69359b708f7
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79.2 MB | Download |
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md5:d0be7a81b8a7d97b9bb5efbe3c06e253
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80.4 MB | Download |
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md5:81e78ac24bb9765f439ca50f20936ecd
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81.7 MB | Download |
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md5:8508d92f94779ca2882f0b4d0acc702f
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73.9 MB | Download |
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md5:86b3191a5d9dcc6a5296a21190b38656
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89.5 MB | Download |
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md5:3da5988523ab7db584c58ab36d291e25
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71.5 MB | Download |
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md5:0f559582c314c011c747a88e3cfcc5de
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73.2 MB | Download |
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md5:62c0dfee0a40e401d1406a7e6965eff1
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71.2 MB | Download |
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md5:b07ab1f98821ea6f0c5c3290e4d8fd2c
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69.9 MB | Download |
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md5:9f787d6f5bcd37c6adfd8e0156165a82
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71.3 MB | Download |
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md5:dcc152cc31737e3022473761dba1541a
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72.0 MB | Download |
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md5:852811a4714d6ada92394565e30b8411
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68.2 MB | Download |
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md5:53cb6e9b7a7e4e8d117a2328e07b161d
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70.0 MB | Download |
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md5:d27100c3a219bb595e7bd4ddad71b202
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78.9 MB | Download |
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md5:c8c3fa211608acdd2bf8f2c4013fac93
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67.8 MB | Download |
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md5:7a787c5c9231b9ba609a5db11c34ff8b
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70.0 MB | Download |
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md5:010a1f25e4bf17c6c254f1f9e93e6f64
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67.2 MB | Download |
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md5:17ae2ee3cb582e845a558ecb5a924404
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68.1 MB | Download |
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md5:e2eb25256313fab54eaf984e4473d692
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69.6 MB | Download |
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md5:e6ccd0863492a8a15a3fbce3f93b6e8f
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71.2 MB | Download |
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md5:b7deb15d954f3b08b6631eedad691d04
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68.6 MB | Download |
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md5:0417a4eedae205811c1b7da8855d6100
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70.0 MB | Download |
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md5:7b55156027b637a812ff1a187d51b3f9
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69.2 MB | Download |
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md5:f9ea6611444b8e9002c9a7ba1f95603f
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72.1 MB | Download |
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md5:482fa418a61c57195517f1b41e759c42
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70.7 MB | Download |
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md5:82f5b29700c068b831cfce92ff401940
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68.9 MB | Download |
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md5:737c632ef108f7d6c7e7d68a5383671f
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70.7 MB | Download |
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md5:cc20d7feb8997463d66d311d6389c907
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67.9 MB | Download |
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md5:c086804ec4e2866e6d471e815fa8e16b
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72.7 MB | Download |
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md5:ac4a63e54fa40b7963ff3d25a4f7f188
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69.2 MB | Download |
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md5:98998129a8eeb6ecae1765ef936a245a
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73.8 MB | Download |
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md5:91a36e47c51b4673656554694afd5ff1
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84.0 MB | Download |
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md5:129f2e39f0b6ad8ed29304ecc72b422d
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79.5 MB | Download |
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md5:92b76ceb03d41b386b06e92a34ab2584
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71.4 MB | Download |
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md5:f647c59e7e26f2e98a8297ac5cebcb76
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71.3 MB | Download |
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md5:42a722bda68dde695162a912e987a4d0
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69.7 MB | Download |
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md5:054d8fa8aeb1d943b87f452294f38be0
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73.6 MB | Download |
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md5:ed0dbee30e86f1f7ab3179396c5a51c0
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73.1 MB | Download |
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md5:70f28adc4bdb672520c2a46d09d4d2cd
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70.6 MB | Download |
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md5:ca4a2a8e2e0b28a4aeae18ee9abe2df2
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72.0 MB | Download |
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md5:7a85bec110a7b7d2ec60d699d81f96e0
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70.6 MB | Download |
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md5:bf7b09dae4eaf91bc035240c31e84d74
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71.7 MB | Download |
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md5:9310a5c48d52b66bf5c7512855822ec3
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74.5 MB | Download |
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md5:585e77fd4ed6b13ac8541c63f433700c
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70.7 MB | Download |
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md5:515fc199271d61cabf11b7f399c1c8cd
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72.8 MB | Download |
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md5:0ac618188c29ce56ad6f9147ffe6ee84
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72.7 MB | Download |
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md5:cd500d0d099a3d133ba46562d9068c6a
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83.6 MB | Download |
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md5:1305794c8f4e15947123d0f3558a9443
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82.1 MB | Download |
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md5:51c09c2dca83b09f1d799d4be7a5462c
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79.9 MB | Download |
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md5:40c6dfd81fb9142357173053479e4b47
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81.6 MB | Download |
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md5:bec90391839eec04d0b2babf260a7db2
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78.0 MB | Download |
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md5:404c32878c594b14cc46ef292577b797
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79.5 MB | Download |
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md5:b7553e5dff2bba57f5b688effb1bf177
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80.1 MB | Download |
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md5:c374f6c8f9a0fd230046d45ab2218834
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76.4 MB | Download |
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md5:de80b6c44b6f791c80dd5ba182c13325
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79.1 MB | Download |
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md5:073d12186a59253cb6d2b07692276302
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62.3 MB | Download |
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md5:2ae2a46c36327e07f977fe4dac00d238
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78.0 MB | Download |
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md5:1f033cbc9d91bca25b27b341a3000bce
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95.3 MB | Download |
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md5:107cfa7c62429bb67aa22206006a2d47
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79.0 MB | Download |
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md5:95eb8cf0cb5c9c09ea45bd6ec06e9b7a
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82.0 MB | Download |
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md5:f907158984f1b8fc990f02b17ab0fc1c
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75.5 MB | Download |
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md5:9b4d64f8468140a06c07c30deb0a8bb3
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79.6 MB | Download |
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md5:60f1b50017963ba8c19ddd5bee105075
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82.1 MB | Download |
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md5:13cf6291094730a1c90924db22fd7f58
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85.7 MB | Download |
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md5:44b0c6d9b8799fcda7c5a84e0014f148
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80.9 MB | Download |
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md5:b3e64573a7fe57462570b13ed5d7bb39
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122.7 MB | Download |
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md5:f5bfee9c17fcc4a7c43de8eabb3b4ce0
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98.4 MB | Download |
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md5:5a9a27b2771623f4027d9b7dd075d3e9
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92.7 MB | Download |
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md5:c605b1762ae403f3cfabb078e730d8f0
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93.5 MB | Download |
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md5:873f50d56c9c095a6e6e814d709c6897
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100.5 MB | Download |
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md5:cc7e4a6a0d30f34a28792fc7fbc87367
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93.4 MB | Download |
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md5:b89b15a69b96307a7f502700ef5f9076
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120.8 MB | Download |
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md5:d1d07301d3a4fcec9c5554ef038e0e1d
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91.7 MB | Download |
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md5:3986f1580046e29969a659d2322fdf86
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123.2 MB | Download |
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md5:52854b32518b4dff446555e2872d1a54
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91.3 MB | Download |
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md5:ad6e0ccd67f258b0bc20061a0fbd7cac
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118.8 MB | Download |
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md5:8ee3d749e0b8b6051438890fdec70d96
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125.1 MB | Download |
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md5:8f3f8f30c28f4dde056f1f299251651d
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117.8 MB | Download |
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md5:54c921de1c075f835178ecdcf5d5c8c1
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123.8 MB | Download |
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md5:d007dfd9f8c460da06a14198201f1734
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109.1 MB | Download |
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md5:25a62c71cf8ae33e7543a1e8febc6de0
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113.2 MB | Download |
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md5:b9722a94283e38afba19d66b4cdb1111
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85.3 MB | Download |
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md5:863c86e2e079f769a61e07e5463a5125
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106.6 MB | Download |
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md5:1cfedae806873dd8e84cb689641e127a
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103.9 MB | Download |
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md5:2ee0504342a17b4c605397fb77a8bf4d
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106.8 MB | Download |
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md5:3a5104dcae7f391cfbdbdcc3351bb817
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104.3 MB | Download |
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md5:4d8dc05287cce033177611b476d05771
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96.6 MB | Download |
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md5:10a0e3662b27bbf05e4459c02ad4505b
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106.0 MB | Download |
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md5:77db9cb4b03815462478a71a377d308c
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102.8 MB | Download |
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md5:dfd461359875a77a8912f6336a624c58
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95.7 MB | Download |
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md5:00cd9a8254fdd1fa49e1714136a37683
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75.0 MB | Download |
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md5:2fdc3df92698cef3085dd46599613594
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106.6 MB | Download |
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md5:365fdad80892cc2c88febdd78eddbe57
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96.1 MB | Download |
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md5:306665f088207aa97cb765c362bc3ab4
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88.1 MB | Download |
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md5:13504bb9549606356c0ad66f5edad6f6
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101.9 MB | Download |
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md5:670a28a5d2e1af1e3253bf510883c588
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100.7 MB | Download |
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md5:e83e387b1e4d6629bf6b8abb326d2423
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125.0 MB | Download |
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md5:d0c20bba3f4edea6b577b907647eafeb
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93.9 MB | Download |
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md5:67d3dbab65fd630b5db5e424654d7c6b
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100.2 MB | Download |
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md5:df9bdb690b6aa2a37799bdb340dc61d0
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101.5 MB | Download |
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md5:0945e22bf4b757ed620901ce3299dc4d
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119.3 MB | Download |
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md5:f2d70381f742969d2aaabfb47faaa276
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102.9 MB | Download |
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md5:203191079cea36a979677db8b0632132
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79.5 MB | Download |
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md5:5cb6125c2df0c433ac7f0dcbea4a5094
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121.7 MB | Download |
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md5:5a508b5edbb67818a075681b9efa365e
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124.7 MB | Download |
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md5:e3941a086c14412b31228d4a79bbff69
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91.0 MB | Download |