Hybrid laser-ultrasound cavitation for cloud evolution studies
Authors/Creators
- 1. University of Dundee
- 2. University of Bergen
Description
We report on the development of an instrument for hybrid ‘sonoptic’ cavitation studies. A focused ultrasound transducer is housed in a custom-built chamber, which permits optical access to the focal volume, without perturbing the propagating acoustic waves. This configuration allows pulsed-laser irradiation of the liquid at the focus, and simultaneous high-speed observation of cavitation activity in this region. In this paper we provide a brief description of the apparatus and present preliminary data on the distinct cavitation regimes we have observed; specifically, laser-induced cavitation in an established field, and a new phenomenon that we refer to as laser-nucleated acoustic cavitation. The former involves a laser-pulse of energy above the threshold value for optical breakdown for the medium, in a pre-established ultrasound field. Here, a cavity rapidly expands to a maximum diameter of a few 100 μms, from the plasma generated on absorption of the optical energy, and collapses to form debris that is subsequently driven by the ultrasound radiation. By contrast, laser-nucleated acoustic cavitation is initiated by a pulse of energy below the breakdown threshold, in a pre-established field. For this regime, either form of radiation does not result in cavitation activity without the other. In combination, the role of the laser-pulse is to initiate activity which is dominated by the ultrasound exposure from the outset. Crucially, the spatial and temporal precision afforded to the occurrence of cavitation by laser-nucleation, allows us to consolidate our assertion of acoustic cavitation. With observations at unprecedented resolutions, we compare the size of constituent cavities within a single acoustical cycle to theoretical predictions, based on the frequency of the ultrasound driving the activity. It is expected that such observations will contribute to a greater understanding of cavitation in focused ultrasound, including for potential future therapeutic applications.
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Related works
- Is part of
- Book: 10.5281/zenodo.4779072 (DOI)
References
- ter Haar, G., Ultrasound focal beam surgery. Ultrasound Med Biol, 1995. 21(9): p. 1089-1100.
- Coussios, C. et al., Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound. Int J Hyperthermia, 2007. 23(2): p. 105-120.
- McGlaughlin, J. et al., A study of bubble activity generated in ex-vivo tissue by high intensity focused ultrasound. Ultrasound Med Biol, 2010. 36(8): p. 1327-1344.
- Holt, R. and R., Roy, Measurements of bubble-enhanced heating from focused MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol, 2001. 27(10): p. 1399-1412.
- Leighton, T, Acoustic Bubble. Academic Press, 1994, London.
- Chen, H. et al., High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer. Ultrasonics, 2006. 14: p. 291-297.
- Lee, J. et al., Determination of the size distribution of sonoluminescence bubbles in a pulsed acoustic field. J Am Chem Soc, 2005. 127: p. 16810-16811.
- Brotchie, A. et al., Effect of power and frequency on bubble-size distributions in acoustic cavitation. Phys Rev Lett, 2009. 102: p. 084302.
- Chen, W. et al., The disappearance of ultrasound contrast microbubbles: observation of bubble dissolution and cavitation nucleation. Ultrasound Med Biol, 2002. 28(6): p. 798-803.
- Fujimoto, J. et al., Time-resolved studies of Nd:YAG laser-induced breakdown. Invest. Opthalmol. Vis. Sci., 1985. 26: p. 1771-1777.
- Brujan E. et al., Dynamics of laser-induced cavitation bubbles near an elastic boundary. J Fluid Mech, 2001. 433: p. 251-281.
- Vogel, A. et al., Shock wave emission and cavitation bubble formation by picoseconds and nanosecond optical breakdown in water. J Acoust Soc Am, 1996. 100(1): p. 148-165.
- Gerold, B. et al., Laser-nucleated acoustic cavitation in focused ultrasound. Rev Sci Inst, 2011. 82(4): p. 044902.
- Palanchon, P. et al., Optical observations of acoustical radiation force effects on individual air bubbles. IEEE UFFC, 2005. 52(1): p. 104-110.