Dataset related to article "Characterization of Myocardial Injury in Patients With COVID-19 "
- Gennaro Giustino1
- Lori B Croft1
- Giulio G Stefanini2
- Renato Bragato3
- Jeffrey J Silbiger4
- Marco Vicenzi5
- Tatyana Danilov6
- Nina Kukar7
- Nada Shaban8
- Annapoorna Kini9
- Anton Camaj9
- Solomon W Bienstock9
- Eman R Rashed10
- Karishma Rahman1
- Connor P Oates1
- Samantha Buckley1
- Lindsay S Elbaum11
- Derya Arkonac6
- Ryan Fiter1
- Ranbir Singh1
- Emily Li1
- Victor Razuk1
- Sam E Robinson4
- Michael Miller1
- Benjamin Bier1
- Valeria Donghi3
- Marco Pisaniello12
- Riccardo Mantovani3
- Giuseppe Pinto3
- Irene Rota12
- Sara Baggio3
- Mauro Chiarito3
- Fabio Fazzari3
- Ignazio Cusmano13
- Riccardo Mantovani3
- Giuseppe Pinto3
- Irene Rota14
- Sara Baggio3
- Mauro Chiarito3
- Fabio Fazzari3
- Ignazio Cusmano15
- Mirko Curzi3
- Richard Ro1
- Waqas Malick1
- Mazullah Kamran16
- Roopa Kohli-Seth17
- Adel M Bassily-Marcus17
- Eric Neibart1
- Gregory Serrao1
- Gila Perk1
- Donna Mancini1
- Vivek Y Reddy1
- Sean P Pinney1
- George Dangas1
- Francesco Blasi18
- Samin K Sharma1
- Roxana Mehran1
-
Gianluigi Condorelli2
- Gregg W Stone1
- Valentin Fuster19
- Stamatios Lerakis1
- Martin E Goldman1
- 1. The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York
- 2. IRCCS Humanitas Research Hospital, via Manzoni 56,20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele – Milan, Italy
- 3. IRCCS Humanitas Research Hospital, via Manzoni 56, 20072 Rozzano (Mi) - Italy
- 4. Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York City, New York
- 5. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Dyspnea Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
- 6. Mount Sinai Beth Israel Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 7. Mount Sinai West Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 8. Mount Sinai Queens Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 9. The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 10. The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York; Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 11. The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York; Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York City, New York
- 12. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
- 13. Dyspnea Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
- 14. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
- 15. Dyspnea Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
- 16. Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 17. Institute for Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
- 18. University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy
- 19. The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York City, New York; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Description
This record contains raw data related to article “Characterization of Myocardial Injury in Patients With COVID-19"
Background: Myocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However, the mechanisms of myocardial injury remain unclear and prior studies have not reported cardiovascular imaging data.
Objectives: This study sought to characterize the echocardiographic abnormalities associated with myocardial injury and their prognostic impact in patients with COVID-19.
Methods: We conducted an international, multicenter cohort study including 7 hospitals in New York City and Milan of hospitalized patients with laboratory-confirmed COVID-19 who had undergone transthoracic echocardiographic (TTE) and electrocardiographic evaluation during their index hospitalization. Myocardial injury was defined as any elevation in cardiac troponin at the time of clinical presentation or during the hospitalization.
Results: A total of 305 patients were included. Mean age was 63 years and 205 patients (67.2%) were male. Overall, myocardial injury was observed in 190 patients (62.3%). Compared with patients without myocardial injury, those with myocardial injury had more electrocardiographic abnormalities, higher inflammatory biomarkers and an increased prevalence of major echocardiographic abnormalities that included left ventricular wall motion abnormalities, global left ventricular dysfunction, left ventricular diastolic dysfunction grade II or III, right ventricular dysfunction and pericardial effusions. Rates of in-hospital mortality were 5.2%, 18.6%, and 31.7% in patients without myocardial injury, with myocardial injury without TTE abnormalities, and with myocardial injury and TTE abnormalities. Following multivariable adjustment, myocardial injury with TTE abnormalities was associated with higher risk of death but not myocardial injury without TTE abnormalities.
Conclusions: Among patients with COVID-19 who underwent TTE, cardiac structural abnormalities were present in nearly two-thirds of patients with myocardial injury. Myocardial injury was associated with increased in-hospital mortality particularly if echocardiographic abnormalities were present.
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Additional details
Related works
- Is supplement to
- 3312-1710 (ISSN)
- 10.1016/j.jacc.2020.08.069 (DOI)