Published May 6, 2021 | Version 1.2.0
Software Open

CostaLab/CrossTalkeR

  • 1. Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen, 52074 Germany
  • 2. Department of Hematology, Erasmus Medical Center, Rotterdam, 3015GD, the Netherlands
  • 3. Department of Computer Science, RWTH Aachen University, Germany

Description

CrossTalkeR is a framework for network analysis and visualisation of LR networks. CrossTalkeR identifies relevant ligands, receptors and cell types contributing to changes in cell communication when contrasting two biological states: disease vs. homeostasis. A case study on scRNA-seq of human myeloproliferative neoplasms reinforces the strengths of CrossTalkeR for characterisation of changes in cellular crosstalk in disease state.

Updated version @ https://github.com/CostaLab/CrossTalkeR 

Files

Files (38.8 MB)

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Additional details

Related works

Is derived from
Software: https://github.com/CostaLab/CrossTalkeR (URL)