Published May 3, 2021 | Version NMR FID DATA - BRUKER SPECTROMETER
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Unified Approach for the Total Synthesis of bis-THF C15 Acetogenins: a Chloroenyne from Laurencia Majuscula, Laurendecumenyne B and Laurefurenynes A/B

Authors/Creators

  • 1. National Chemical Laboratory, CSIR

Description

A highly diastereoselective total synthesis of several bis-THF C15 acetogenin class of natural products: chloroenyne from Laurencia Majuscula, laurendecumenyne B, laurefurenynes A/B and synthesis of an advanced intermediate reported in the earlier total synthesis of (E/Z)-elatenynes (formal Synthesis) are described. The salient features in the synthesis include epoxide opening, Birch reduction, Sharpless asymmetric dihydroxylation-cycloetherification, SN2 halogenation and a (relay-) cross-metathesis.

Notes

See the article at: https://doi.org/10.1055/a-1500-1407

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Journal article: 10.1055/a-1500-1407 (DOI)