Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"
- Sara Carloni1
- Alice Bertocchi2
- Sara Mancinelli3
- Martina Bellini1
- Marco Erreni2
- Antonella Borreca4
- Daniele Braga2
- Silvia Giugliano2
- Alessandro M Mozzarelli1
- Daria Manganaro5
- Daniel Perez Fernandez5
- Federico Colombo6
- Antonio Di Sabatino7
- Diego Pasini8
- Giuseppe Penna2
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Michela Matteoli4
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Simona Lodato1
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Maria Rescigno1
- 1. IRCCS Humanitas Research Hospital, via Manzoni 56,20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele – Milan, Italy
- 2. IRCCS Humanitas Research Hospital, via Manzoni 56, 20072 Rozzano (Mi) - Italy
- 3. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele – Milan, Italy
- 4. IRCCS Humanitas Research Hospital -, via Manzoni 56, 20089 Rozzano, Milan, Italy AND Institute of Neuroscience -CNR
- 5. IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy
- 6. Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20089 Pieve Emanuele (Milan), Italy
- 7. Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy
- 8. IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy AND University of Milan, Department of Health Sciences, Via A. di Rudini 8, 20142 Milan, Italy
Description
This record contains raw data related to article “ Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"
Up to 40% of patients with inflammatory bowel disease (IBD) present disturbed psychosocial functioning. We previously identified a gut vascular barrier (GVB) which controls the dissemination of bacteria from the intestine to the liver. Here we describe a vascular barrier in the brain choroid plexus (CP) (PVB) which is modulated in response to intestinal inflammation via bacteria-derived lipopolysaccharide (LPS). The inflammatory response induces PVB closure consequently to GVB opening, through the upregulation of the Wnt/b catenin signaling pathway rendering it inaccessible to large molecules. Genetically-driven closure of CP endothelial cells elicits a deficit in short-term memory and anxiety-like behavior, suggesting that PVB closure correlates with mental deficits. IBD-related mental symptoms may thus be the consequence of a deregulated gut-brain vascular axis.
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