ALTERATIONS IN MANAGING THE DIABETIC MILLITUS BY USING NOVEL TECHNOLOGIES – A SYSTEMATIC REVIEW

Diabetes mellitus is a metabolic disorder with an increasing global prevalence and incidence.  High blood glucose levels are symptomatic of diabetes mellitus as a consequence of inadequate pancreatic insulin secretion or poor insulin-directed mobilization of glucose by target cells.  Type 2 diabetes mellitus (T2DM) is a fast-growing disease and a leading global public health concern. Multiple complications are associated with T2DM. Patient education with lifestyle modifications and pharmacotherapy are the main methods for the treatment of patients afflicted with T2DM. Therapy of type 2 diabetes like DPP-4 inhibitors its action is mediated by increasing levels of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)  Layer tablets are used for preventing any type of incompatibilities between drugs & also for sustained release in which one layer serves as immediate release “initial dose” layer & other layer serves as “maintenance dose” layer. Layer tablet also is forerunners in the field of drug delivery technology due to their advantageous properties like better patient compliance, decrease drug resistance due to less frequent dosing & different release profile with a different release mechanism in a single dose

KEY WORDS :  T2Diabetes Mellitus , DPP-4Inhibitors, Bi-layer tablets , Tri layer tablets.