Published April 9, 2021
| Version v1
Dataset
Open
Data related to article "Cytokine profile in striated muscle laminopathies: new promising biomarkers for disease prediction"
Authors/Creators
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Cristina, Cappelletti1
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Tramacere, Irene1
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Cavalcante,Paola1
- Schena, Elisa
- Politano, Luisa
- Carboni, Nicola
- Gambineri, Alessandra
- D'Amico, Adele
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Mongini, Tiziana
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Vercelli. Liliana
- Biagini, Elena
- Ziacchi, Matteo
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D'Apice, Maria R
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Lattanzi, giovanna
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Mantegazza , Renato E1
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Maggi. Lorenzo1
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Bernasconi, Pia1
- Ruggiero, Lucia
- Ricci, Giulia
- Siciliano, Gabriele
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Boriani, Giuseppe
- 1. Fondazione IRCCS - Istituto Neurologico Carlo Besta di Milano
Description
This database includes a comprehensive profile of circulating pro- and anti-inflammatory molecules (cytokines, chemokines and growth factors) obtained from a group of 53 patients with muscular laminopathy, 10 with non-muscular laminopathy, 22 with other muscular disorders and 35 healthy controls. Data obtained by Luminex multiple immune-assay identify TGF-2, IL-17 and G-CSF as potential biomarkers in discriminating between muscle-related laminopathy and healthy subjects. The different expression of IL-1, IL-4 and IL-8 among the different forms of laminopathy provides a new hint for the understanding of the pathogenic mechanisms underlying the diverse phenotypes caused by LMNA mutations.
Notes
Study supported by Italian Ministry of Health, years 2018-2020 (annual research funding); AIProSaB grants 02/2013 and 03/2016; AIDMED onlus grant 17/2015, Associazione Alessandra Proietti onlus IGM prot. 0002041
Files
RCLR2-Cytokine profile in striated muscle laminopathies_2020062.zip
Additional details
Related works
- Is supplement to
- Journal article: 10.3390/cells9061532 (DOI)