Design, Preparation and Evaluation of Meloxicam Transdermal Patches using Flaxseed/Coriander Oils as Penetration Enhancers

Transdermal drug delivery patch is important for input of suitable drug at significant level to
maintain plasma concentration for therapeutic efficacy. The present study discovered formulation and
evaluation of transdermal patches using chitosan and thiolated chitosan, EC and PVP, Eudragit and PVP
polymers in different ratios. Flaxseed oil and coriander oil were used as penetration enhancers in different
concentrations (1, 2, 3, 4, 5, and 10%). Physicochemical properties the patches were evaluated for and invitro
drug release. It was decided that amongst the formulations, FMLXE23, FLMXE35 and FMLXE47
which have 5% of flaxseed oil having maximum flux through rabbit skin while formulation FMLXE30,
FMLXE42 and FMLXE54 containing 10% of coriander oil showed maximum flux. The drug mechanism
was non-Fickian. The polymers used in the formulations have controlled the release pattern in transdermal
patches. Flaxseed oil showed maximum flux at concentration 5% and coriander oil displayed maximum
flux at 10% concentration.