CLINICAL BIOCHEMISTRY IMPACT OF GLYCATED ALBUMIN AS A POTENTIAL BIOMARKER IN DIABETES

Diabetes mellitus (DM) is a chronic metabolic disease that represents a high global incidence rate. Glycated hemoglobin (HbA1C)  is the long - term glucose reference test  it appears to be associated with chronic diabetes complications,(Hb A1C) is not recommended for use in clinical situations that may interfere with metabolism of hemoglobin,  as in hemolytic anemia, secondary or iron deficiency, hemoglobinopathies, pregnancy, and uremia. Glycated albumin (GA)is ashort term blood sugar test that is not affected by cases that incorrectly change A1c leveles.GA is the top part of glucose of fructosamine .it is meashured by the standard enzyme methodology , easy and fast performance. These Laboratory properties have ensured the spotlight on GA in studies from the past decade,as asign of monitoring and screening for diabetes as well as predicting long –term outcomes of the disease . The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM.

Key words: Diabetes mellitus; glycated albumin; glycated proteins