Curated Envirotox database and compound specific Human-Biota TTC from the LIFE+ Vermeer project

In the paper "Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools" by Baderna et al., 2021 (https://doi.org/10.3390/molecules26071928)  we are proposing a strategy to define the Human-Biota TTCs (HB-TTCs) as concentrations of organic chemicals in freshwater preserving both humans and ecological receptors at the same time. Two sets of thresholds were derived: general HB-TTCs as preliminary screening levels for compounds with no eco- and toxicological information, and compound-specific HB-TTCs for chemicals with known hazard assessment, in terms of Predicted No effect Concentration (PNEC) values for freshwater ecosystems and acceptable doses for human health. The proposed strategy is based on freely available public data and tools to characterize and group chemicals according to their toxicological profiles. Five generic HB-TTCs were defined, based on the ecotoxicological profiles reflected by the Verhaar classes, and compound-specific thresholds for more than 400 organic chemicals with complete eco- and toxicological profiles.

The list of >400 compound-specific HB-TTC is included in this dataset.

This work was funded by the LIFE+ Projects VERMEER [LIFE16/ENV/IT/000167] and was conducted under the framework of the Italian Institute For Planetary Health (IIPH).

reference: Baderna D, Faoro R, Selvestrel G, Troise A, Luciani D, Andres S, Benfenati E. Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools. Molecules. 2021; 26(7):1928. https://doi.org/10.3390/molecules26071928