Published March 19, 2021 | Version v1
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APPLICATION OF PLATELET-RICH PLASMA (PRP) IN CORNEAL LESIONS – A REVIEW

Authors/Creators

  • 1. University of Forestry, Faculty of Veterinary Medicine, Sofia, Bulgaria

Contributors

  • 1. University of Forestry

Description

Platelet-rich plasma (PRP) is an autologous blood product rich in proteins and growth factors. Its appli-cation has been the subject of many studies in the field of veterinary ophthalmology to stimulate tissue healing and regeneration. Due to its anatomical features (lack of blood vessels), the cornea is among the most susceptible to damage structures of the eye. Therefore, the study of the impact of various regenerative therapies (autologous blood products, serums, stem cells, amniotic and pericardial membranes) on corneal lesions is important not only scientifically, but also practically for veterinarians. Numerous reports described the healing effect of PRP on corneal lesions. The present article is a brief overview of the various methods of application of PRP (eye drops, injections, activated clot form) in ophthalmology and the results obtained.

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References

  • Alio, J. L., M. Abad, A. Artola, J. L. Rodriguez-Prats, S. Pastor, J. Ruiz-Colecha. (2007). Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology, 114(7), 1286–1293.
  • Alio, J. L., F. Arnalich-Montiel, A. Rodriguez. (2012). The Role of "Eye Platelet Rich Plasma" (E-PRP) for Wound Healing in ophthalmology. Current pharmaceutical biotechnology, 13(7), 1257–1265.
  • Alio, J. L., A. Rodrigez, L. Martinez. (2013). Bovine pericardium membrane (tutopatch) combined with solid platelet-rich plasma for the management of perforated corneal ulcers. Cornea, 32(5), 619–624.
  • Alio, J. L., A. Rodriguez, A. Abdelghany, R. Oliveira. (2017). Autologous Platelet-Rich Plasma Eye Drops for the Treatment of Post-LASIK Chronic Ocular Surface Syndrome. Journal of ophthalmol-ogy, 2017.
  • Alsousou, J., M. Thompson, P. Hulley, A. Noble, K. Willett. (2009). The biology of platelet-rich plasma and its application in trauma and orthopedic surgery: a review of the literature. The Journal of bone and joint surgery. British volume, 91(8), 987–996
  • Alsousou, J., A. Ali, K. Willett, P. Harrison. (2013). The role of platelet-rich plasma in tissue re-generation. Platelets, 24(3), 173–182.
  • Aminkov, K., B. Aminkov, N. Zlateva-Panayotova, C. Botev. (2016). Application of platelet-rich plasma (PRP) in treating of a complicated postoperative wound in a cat: a clinical case. Tradition and Modernity in Veterinary Medicine, vol.1, No 1(1), 33–37.
  • Anitua, E. (1999). Plasma is rich in growth factors: preliminary results of use in the preparation of future sites for implants. International Journal of Oral and maxillofacial Implants, 14(4), 529–535.
  • Arnalich, F., A. Rodriguez, A. Luque-Rio, J. Alio. (2016). Solid platelet-rich plasma in corneal surgery. Ophthalmology and therapy, 5(1), 31–45.
  • Cavallo, C., A. Roffi, B. Grigolo, E. Mariani, L. Pratelli, G. Merli, E. Kon, M. Marcacci, G. Filardo. (2016). Platelet-rich plasma: the choice of activation method affects the release of bioactive mole-cules. BioMed research international, 2016.
  • Charalambidou, G., E. Kofidou, N. Papaioannou, V. Karampatakis, A. Komnenou. (2018). The ef-fect of intrastromal PRP and oral doxycycline in corneal wound healing after alkali burn. Journal of the Hellenic Veterinary Medical Society, 69(4), 1213–1226.
  • Dhurat, R., M. Sukesh. (2014). Principles and methods of preparation of platelet-rich plasma: a review and the author's perspective. Journal of cutaneous and aesthetic surgery, 7(4), 189–197
  • Diegelmann, R., M. Evans. (2004). Wound healing: an overview of acute, fibrotic and delayed heal-ing. Frontiers in Bioscience: A Journal and Virtual Library. 2004 Jan; 9:283–289. DOI: 10.2741/1184.
  • Du, L., Y. Miao, X. Li, P. Shi, Z. Hu. (2018). A novel and convenient method for the preparation and activation of PRP without any additives: temperature-controlled PRP. BioMed research inter-national, 2018:1–12.
  • Ehrenfest, D., G. Sammartino, J. Shibli, H. Wang, D. Zou, J. Bernard. (2013). Guidelines for the publication of articles related to platelet concentrates (Platelet-Rich Plasma-PRP, or Platelet-Rich Fibrin-PRF): the international classification of the POSEIDO. Poseido J, 1, 17–28.
  • Elbassiouny, K. A. (2017). Effect of Platelet-Rich Plasma on Healing of Corneal Wound: Experi-mental Study. In 2017 ASCRS ASOA Symposium and Congress. ASCRS
  • Englert, S. J., T. Estep, C. Ellis-Stoll. (2005). Autologous platelet gel applications during cardiovas-cular surgery: effect on wound healing. The journal of extra-corporeal technology, 37(2), 148–152
  • Ferrari, M., S. Zia, M. Valbonesi, F. Henriquet, G. Venere, S. Spagnolo, M. Grasso, I. Panzani. (1987). A new technique for hemodilution, preparation of autologous platelet-rich plasma, and in-traoperative blood salvage in cardiac surgery. The International Journal of artificial organs, 10(1), 47–50.
  • Foster, T., B. Puskas, B. Mandelbaum, M. Gerhardt, A. Rodeo. (2009). Platelet-rich plasma: from basic science to clinical applications. The American journal of sports medicine, 37(11), 2259–2272
  • Gimeno, F., S. Gatto, J. Ferro, J. Croxatto, J. Gallo. (2006). Preparation of platelet-rich plasma as a tissue adhesive for experimental transplantation in rabbits. Thrombosis Journal, 4(1), 18.
  • Girgin, M., K. Binnetoglu, K. Duman, B. Kanat, Z. Cetinkaya, R. Ayten, Y. Ilhan, N. Ilhan, I. Seker, N. Timurkaan. (2016). Effects of platelet-rich plasma on fascial healing in rats with fecal peritonitis. Acta cirurgica brasileira, 31(5), 314–319.
  • Hatakeyama, I., E. Marukawa, Y. Takahashi, K. Omura. (2014). Effects of platelet-poor plasma, platelet-rich plasma, and platelet-rich fibrin on the healing of extraction sockets with buccal dehis-cence in dogs. Tissue Engineering Part A, 20(3–4), 874–882.
  • Ibrahim, M., N. Elswaidy. (2019). A histological and immunohistochemical study of the effect of platelet-rich plasma on a corneal alkali burn in adult male albino rats. Egyptian Journal of Histol-ogy, 42(2), 482–495.
  • Liao, H. T., K. Marra, J. Rubin. (2014). Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review. Tissue Engineering Part B: Reviews, 20(4), 267–276.
  • Lubkowska A., B. Dolegowska, G. Banfi. (2012). Growth factor content in PRP and their applica-bility in medicine. J Biol Regul Homeost Agents, 26(2 Suppl 1), 3S–22S.
  • Man, D., H. Plosker, J. Winland-Brown. (2001). The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plastic and reconstruc-tive surgery, 107(1), 229–37.
  • Marinov, G. (2019). Application of Platelet-rich Plasma and Platelet-Rich Fibrin for Fracture Treatment. Veterinarna praktika, 3/2019, 30–35 (in bulgarian)
  • Marinov, G. (2020). Use of Bone Marrow (BM) anc Concentrated Bone Marrow Aspirate (CBMA) for Treatment of Critical Long Fractures. Tradition and Modernity in Veterinary Medicine, vol. 5, No 1(8), 86–91.
  • Marquez-de-Aracena R., I. Montero-de-Espinosa, M. Muñoz, G. Pereira. (2007). Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results. Archivos de la Sociedad Espanola de Oftalmologia, 82(8), 475–481
  • Marx, R. (2001). Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant dentistry, 10(4), 225–228.
  • Marx, R. (2004). Platelet-rich plasma: evidence to support its use. Journal of oral and maxillofacial surgery, 62(4), 489–496.
  • Nurden, A. T. (2011). Platelets, inflammation and tissue regeneration. Thrombosis and haemostasis, 105(S 06), S13–S33.
  • Oie, Y., K. Nishida. (2013). Regenerative medicine for the cornea. BioMed research international, 2013
  • Pavlovic, V., M. Ciric, V. Jovanovic, P. Stojanovic. (2016). Platelet rich plasma: a short overview of certain bioactive components. Open Medicine, 11(1), 242–247
  • Peng, W., I. Kim, H. Cho, J. Seo, D. Lee, J. Jang, S. Park. (2016). The healing effect of platelet-rich plasma on xenograft in peri-implant bone defects in rabbits. Maxillofacial plastic and reconstructive surgery, 38(1), 16.
  • Piao, L., H. Park, C. Jo. (2017). Theoretical prediction and validation of cell recovery rates in pre-paring platelet-rich plasma through a centrifugation. PloS one, 12(11).
  • Ribeiro, M., V. Melo, M. Barbosa, M. Tozzi, M. Ramos, N. Gaia, V. Santos, W. Neri, F. Barbosa, E. Ribeiro. (2017). The use of platelet rich-plasma in Ophthalmology: a literature review. Revista Brasileira de Oftalmologia, 76(6), 319–324.
  • Swank, A., Hosgood, G. (1996). Corneal wound healing and the role of growth factors. Compend Small Anim 18(9):1007–1016.
  • Tanidir, S. T., N. Yuksel, O. Altintas, D. Yildiz, E. Sener, Y. Caglar. (2010). The effect of subcon-junctival platelet-rich plasma on corneal epithelial wound healing. Cornea, 29(6), 664–669.
  • Weibrich, G., T. Hansen, W. Kleis, R. Buch, W. Hitzler. (2004). Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone, 34(4), 665–671.
  • Wilson, S., А. Last. (2004). Management of corneal abrasions. American family physician, 70(1), 123–128.
  • Wróbel-Dudzińska, D., J. Alio, A. Rodriguez, E. Suchodoła-Ratajewicz, E. Kosior-Jarecka, B. Rym-gayłło-Jankowska, A. Ćwiklińska-Haszcz, T. Żarnowski. (2018). Clinical efficacy of platelet-rich plasma in the treatment of neurotrophic corneal ulcer. Journal of ophthalmology, 2018.
  • Wu, T. E., C. Chen, C. Hu, C. Cheng. (2015). Easy-to-prepare autologous platelet-rich plasma in the treatment of refractory corneal ulcers. Taiwan journal of ophthalmology, 5(3), 132–135.