Dryad
Published March 17, 2021 | Version v1
Dataset Open

Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation

Authors/Creators

  • 1. University of Gothenburg
  • 2. Pompeu Fabra University
  • 3. University of Notre Dame
  • 4. University of Sheffield

Description

Due to their effects on reducing recombination, chromosomal inversions may play an important role in speciation by establishing and/or maintaining linked blocks of genes causing reproductive isolation (RI) between populations. This view fits empirical data indicating that inversions typically harbour loci involved in RI. However, previous computer simulations of infinite populations with 2-4 loci involved in RI implied that, even with gene flux as low as 10^(-8) per gamete, per generation between alternative arrangements, inversions may not have large, qualitative advantages over collinear regions in maintaining population differentiation after secondary contact. Here, we report that finite population sizes can help counteract the homogenizing consequences of gene flux, especially when several fitness-related loci reside within the inversion. In these cases, the persistence time of differentiation after secondary contact can be similar to when gene flux is absent and notably longer than the persistence time without inversions. Thus, despite gene flux, population differentiation may be maintained for up to 100,000 generations, during which time new incompatibilities and/or local adaptations might accumulate and facilitate progress towards speciation. How often these conditions are met in nature remains to be determined.

Notes

There are four versions of the main code, each version being reserved for a separate model version. The .m file called "Analyze_WeightedTime.m" serves to compute the average weighted time of differentiation based on multiple model realisations. 

Funding provided by: Svenska Forskningsrådet Formas
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001862
Award Number: 2019-00882

Funding provided by: Hasselblad Foundation*
Crossref Funder Registry ID:
Award Number: Female Scientist 2019-2020

Funding provided by: Swedish Research Council*
Crossref Funder Registry ID:
Award Number: 2018-05973

Funding provided by: European Regional Development Fund
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100008530
Award Number: FCOMP-01-0124-FEDER-014272

Funding provided by: Foundation for Science and Technology
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100019370
Award Number: PTDC/BIA-EVF/113805/2009

Funding provided by: Ministerio de Ciencia e Innovación
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004837
Award Number: BFU2015-68649-P, MINECO/FEDER, UE

Funding provided by: Spanish National Institute of Bioinforma*
Crossref Funder Registry ID:
Award Number: PT17/0009/0020

Funding provided by: Foundation for Science and Technology
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100019370
Award Number: SFRH/BPD/89313/2012

Funding provided by: H2020 Marie Skłodowska-Curie Actions
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100010665
Award Number: 706376

Funding provided by: Ministerio de Ciencia e Innovación
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004837
Award Number: PGC2018-101927-B-I00

Funding provided by: Hasselblad Foundation
Crossref Funder Registry ID:
Award Number: Female Scientist 2019-2020

Funding provided by: Swedish Research Council
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004359
Award Number: 2018-05973

Funding provided by: Spanish National Institute of Bioinforma
Crossref Funder Registry ID:
Award Number: PT17/0009/0020

Files

Files (90.0 kB)

Name Size Download all
md5:0eb536340115c3087a8c055fa40be87e
2.4 kB Download
md5:77a972a2d1bef7aaddff3cb2dc9a1a84
20.7 kB Download
md5:7abe166886f188aad38d719b80e90784
20.8 kB Download
md5:58db634f9912e1e2ddaaff2e262ea0e8
22.5 kB Download
md5:283a71d6b944199ab7c9350221f58f38
22.5 kB Download
md5:4412720897d5b2af1812d6654b3cb1e0
1.1 kB Download

Additional details

Related works

Is cited by
10.1101/2020.08.25.267369 (DOI)
10.1101/2020.08.25.267369 (DOI)