Caffeic Acid

Caffeic acid is one of the pharmacologically active compounds of many medicinal herbs including Echinacea purpurea which was recently recommended as prophylactic treatment for all coronaviruses, including newly occurring strains, such as SARS-CoV-2. Cell-surface heparan sulfate proteoglycans (HSPGs) provide the binding sites for SARS-CoV invasion at the early attachment phase. In addition to ACE2, HSPGs are essential cell-surface molecules involved in SARS-CoV cell entry. Caffeic acid might be a potent molecule for the treatment of new SARS-CoV-2 virus.