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Published February 20, 2021 | Version v1
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FORMULATION AND EVALUATION OF SILVER SULFADIAZINE LADEN TOPICAL FORMULATION FOR BURN WOUND

Description

Plan: Formulation and evaluation and of Silver Sulfadiazine Laden Topical  Formulation for treatment of Burn Wound.

Preface: Burn injuries are very complex. One of the golden treatments in topical burn is silver sulfadiazine (SSD).The hydrogels are non- solid dosage forms that produce a flexible, occlusive film in-situ after application on the skin or any other body surface.

Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMC E5LV, and HPMC E15LV. The prepared hydrogel were evaluated for their various physicochemical properties. The optimized formulation F3 was selected by antimicrobial activity by agar diffusion technique.

Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.

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