Dataset related to article "prognostic factors and outocome in HER2 + in breast cancer with CNS metastases "
- 1. division of oncology & hematology , IRCCS Humanitas Research Hospital, rozzano , milan Italy.
- 2. Biostatistic Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, ltaly
- 3. 0ncology Experimental Therapeutics, Humanitas Research Hospital, Rozzano, Milan, ltaly
- 4. Division of Oncology & Hematology, IRCCS Humanitas Clinica! & Research (enter,Rozzano, Milan, ltaly
- 5. Division of Oncology & Hematology, IRCCS Humanitas Research Hospital,Rozzano, Milan, ltaly AND Humanitas University, Rozzano, Milan, ltaly
- 6. Radiotherapy Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, ltaly
- 7. Division of Oncology & Hematology, IRCCS Humanitas Research Hospital,Rozzano, Milan, ltaly
- 8. Neurosurgery Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, ltaly
- 9. Division of Oncology & Hematology, IRCCS Humanitas Research Hospital,Rozzano, Milan, ltaly AND 6 Humanitas University, Rozzano, Milan, ltaly
Description
this record contains data related to article "prognostic factors and outocome in HER2 + in breast cancer with CNS metastases "
Aim: Trastuzumab prolongs progression-free and overall surviva l in HER2+ breast cancer (BC), but these are associateci with increased distant recurrences and centrainervous system metastases (CNSm). We retro spectively evaluated outcome and prognostic factors in CNSm and non-CNSm patients. Methods: Records of HER2+ BC treated in 2000-2017 were reviewed.Results: 283/1171 (24%) HER2+ BC patients developed metastatic disease. 109/283 patients (39%) have CNSm associateci with worse prognosis and increased risk of death (hazard ratio: 4.7;95% Cl: 3.5-6.4). Prognostic factors were: number of CNSm (single vs multi ple lesions; 3-year overall survival 39 vs 18%; p = 0.003); brain radiation (30 vs 14%; p < 0.001); new HER2-targeting therapies (30.6 vs 22.5%; p = 0.025). Conclusion: Prognosis of BC patients with CNSm has improved using HER2-targeting therapies but remains poor
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Related works
- Is supplement to
- 10.2217/fon-2019-0602 (DOI)
- 32043375 (PMID)