Journal article Open Access
Ashwini Gawade, Ashwin Kuchekar, Prajakta Wagh
Weak aqueous solubility and poor oral bioavailability are main constraints in the production of new products. One technique used to increase the solubility of poorly aqueous soluble drugs is crystallization, which also helps to enhance physicochemical properties such as melting point, tablet power, solubility, stability, bioavailability and permeability with the preservation of pharmacological properties of the active pharmaceutical ingredient. In the medical and pharmaceutical industries, co crystals can be used to improve various properties, such as dissolution rate, melting point, solubility, chemical stability, etc. To increase the solubility of weak aqueous compounds, crystals are used to increase the solubility of aqueous compounds that are weakly soluble. It has the capacity to alter solid-state materials' physical properties. It is also used in taste masking, enhancement of mechanical property, and development and extension of intellectual property.