Dataset related to article "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19"
- Enrico Brunetta1
- Marco Folci1
- Barbara Bottazzi1
- Maria De Santis1
- Giuseppe Gritti2
-
Alessandro Protti3
-
Sarah N Mapelli1
- Stefanos Bonovas3
- Daniele Piovani3
- Roberto Leone1
- Ilaria My3
- Veronica Zanon1
- Gianmarco Spata1
- Monica Bacci1
- Domenico Supino1
- Silvia Carnevale3
- Marina Sironi1
- Sadaf Davoudian1
- Clelia Peano4
- Francesco Landi2
- Fabiano Di Marco5
- Federico Raimondi6
- Andrea Gianatti7
- Claudio Angelini1
- Alessandro Rambaldi8
-
Cecilia Garlanda3
- Michele Ciccarelli1
-
Maurizio Cecconi3
-
Alberto Mantovani3
- 1. IRCCS Humanitas Research Hospital, via Manzoni 56, 20072 Rozzano (Mi) - Italy
- 2. Unit of Hematology, Azienda Ospedaliera Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
- 3. IRCCS Humanitas Research Hospital, via Manzoni 56,20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele – Milan, Italy
- 4. IRCCS Humanitas Research Hospital, via Manzoni 56, 20072 Rozzano (Mi) - Italy AND Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, Milan, Italy.
- 5. Unit of Pneumology, Azienda Ospedaliera Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. AND Department of Health Sciences, University of Milan, Milan, Italy.
- 6. Unit of Pneumology, Azienda Ospedaliera Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
- 7. Unit of Pathology, Azienda Ospedaliera Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
- 8. Unit of Hematology, Azienda Ospedaliera Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. AND Department of Oncology & Hemato-Oncology, University of Milan, Milan, Italy.
Description
This record contains raw data related to articleThis record contains raw data related to article "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19"
Abstract
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.
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Related works
- Is supplement to
- 10.1038/s41590-020-00832-x (DOI)
- 33208929 (PMID)